Endplate role in the degenerative disc disease: A brief review

Table 1 The most common factors taken into account when talking about intervertebral disc degeneration

Factors in the degeneration of the intervertebral disc	Function in the pathological process
Genetic factors	Mutation in genes THBS2, CLIP, ASPN, PARK2, CHTS, COL1A1, COL9A3, COL11A2, COL11 lead to alterations of matrix morphology
Mechanical stress	Smoking, obesity, heavy physical labour, inappropriate flexed posture and physical inactivity
Nutritional disorders	Vessels disease in the vertebral endplate cause a fall in nutritional supply, resulting in a fall in oxygen availability and an increase in lactate concentration, affecting the cell function and synthesis of the extracellular matrix