Sequential occurrence of T790M mutation and small cell lung cancer transformation in EGFR-positive lung adenocarcinoma: A case report

Figure 1 Transformation of chest computed tomography following various regimens. A: The baseline findings on chest computed tomography; B: Partial response (PR) after oral gefitinib 250 mg daily for 4 mo; C: Enlarged lesion in the right upper lobe and increased metastatic nodules after oral gefitinib 250 mg daily for 10.5 mo; D: Enlarged lesion in the right upper lobe with near disappearance of metastasis after oral Osimertinib 80 mg daily for 1 mo; E: Progressive disease (PD) after oral osimertinib 80 mg daily for 3 mo; F: PR after 4 cycles of etoposide + carboplatin; G: PD after 6 cycles of etoposide + carboplatin; H: Stable disease following 4 cycles of docetaxel + carboplatin + anlotinib.