Determination of the ED95 of intranasal sufentanil combined with intranasal dexmedetomidine for moderate sedation during endoscopic ultrasonography

Figure 3 Posterior probability for moderate sedation during endoscopic ultrasonography. After 30 subjects been performed, the dose closest to ED₉₅ was 0.3 μg/kg, with an estimated success probability of 94.9% (95% credibility interval: 88.1%-98.9%). Posterior probability quantiles: 2.5, 25, 50, 75, and 97.5%. Diamond shows estimated ED₉₅. Of note, because of the high success rate encountered with the 0.3 μg/kg dose, the CRM never recommended higher or lower doses. Hence, the 0, 0.1, 0.4 and 0.5 μg/kg dose were never tested, and the posterior probability estimated for these doses are therefore based on the prior probabilities and an extrapolation of the results from the doses using the dose-response model. EUS: Endoscopic ultrasonography.