Laninamivir-induced ischemic enterocolitis: A case report

Table 1 Summary of reports of acute hemorrhagic colitis associated with neuraminidase inhibitors

Patient	Ref.	Publication year	Age (yr)	Sex	Influenza type	Medication used	Time from use of medication to onset	Symptoms	Endoscopic findings
1	[5]	2005	58	Female	A	Oseltamivir	2 d	Diarrhea, abdominal pain, and bloody stools	Longitudinal ulcer from the descending colon to the left side of the transverse colon
2	[7]	2006	28	Female	B	Oseltamivir	2 d	Bloody stools	Erosion, edema, and hemorrhage on the left side of the transverse colon
3	[8]	2007	20	Female	Unknown	Oseltamivir	2 d	Melena and abdominal pain	Erosion, redness, and edema in the descending colon
4	[8]	2007	50	Female	Unknown	Oseltamivir	2 d	Diarrhea, bloody stools, abdominal pain	Erosion and suspicion of ischemic enterocolitis on the left side of the colon
5	[8]	2007	30	Male	Unknown	Oseltamivir	2 d	Abdominal pain, diarrhea, and melena	Edema-like necrotic material and suspicion of ischemic enterocolitis from the sigmoid to the descending colon
6	[8]	2007	28	Female	Unknown	Oseltamivir	2 d	Abdominal pain and bloody stools	Hemorrhage, erosion, edema, and redness on the left side of the transverse colon
7	[8]	2007	50	Female	A	Oseltamivir	2 d	Bloody stools	Redness and ulceration in the descending colon
8	[9]	2013	32	Female	A	Oseltamivir	2 d	Bloody stools and tenesmus	Redness, ulcer, and mucosal edema in the rectum
9	[10]	2007	61	Male	A	Oseltamivir	1 d	Abdominal pain, diarrhea, and bloody stools	Mucosal edema, hemorrhage, and longitudinal ulcer in the entire colon
10	[11]	2011	40	Female	A	Oseltamivir	4 h	Abdominal pain, diarrhea, and bloody stools	Redness, edema, erosion, and hemorrhage in the descending colon
11	[12]	2015	31	Female	A	Oseltamivir	2 d	Abdominal pain and bloody diarrhea	Not performed
12	[13]	2016	12	Male	Unknown	Oseltamivir	4 d	Bloody stools	Not performed
13	[14]	2020	14	Male	A	Oseltamivir	Immediately after (time not specified)	Abdominal pain, nausea, and bloody stools	Findings of ischemic enterocolitis (details not specified)