Perforating and nonperforating indications in repeated surgeries for Crohn’s disease

Table 1 Characteristics of repeated operations patients with Crohn’s disease

	First surgery (n = 386), %	Second surgery (n = 155), %	Third surgery (n = 41), %	P value
Sex				0.405
Man	290 (76.69)	124 (80.00)	33 (80.49)
Female	96 (23.31)	31 (20.00)	8 (19.51)
Age (year)				0.037
A1 (≤ 16)	5 (1.30)	2 (1.29)	0 (00.00)
A2 (17-40)	264 (68.39)	92 (59.35)	20 (48.78)
A3 (> 40)	117 (30.31)	61 (39.35)	21 (51.22)
Appendectomy				0.152
Yes	76 (19.69)	37 (23.87)	13 (31.70)
No	310 (80.31)	118 (76.13)	28 (68.29)
Smoking history				0.576
Never smoker	320 (82.90)	128 (82.58)	37 (90.24)
Past smoker	49 (12.69)	23 (14.84)	3 (7.32)
Active smoker	17 (4.40)	4 (2.58)	1 (2.44)
Preoperative treatment
Immunomodulator	97 (25.13)	48 (30.97)	12 (29.27)	0.362
Enteral Nutrition	178 (46.11)	80 (51.61)	16 (39.02)	0.288
5-aminosalicylates	32 (8.29)	23 (14.84)	4 (9.76)	0.074
Corticosteroids	49 (12.69)	30 (19.35)	7 (17.07)	0.130
Infliximab	8 (2.07)	5 (3.23)	1 (2.44)	0.743
Perianal disease				0.265
Yes	73 (16.77)	39 (25.16)	9 (21.95)
No	313 (83.22)	116 (74.84)	32 (78.05)
Indication for surgery				0.004
Free perforation	65 (16.83)	9 (5.81)	2 (4.87)
Fistula or abscess	107 (27.72)	78 (50.32)	25 (60.97)
Obstruction	162 (41.96)	57 (36.77)	10 (24.39)
Medical intractability	41 (10.62)	5 (3.23)	1 (2.44)
Hemorrhage	11 (2.85)	6 (3.87)	3 (7.32)
Location				0.028
L1 (ileal)	145 (37.56)	56 (36.13)	10 (24.39)
L2 (colonic)	47 (12.18)	7 (4.52)	5 (12.20)
L3 (ileocolonic)	194 (50.26)	92 (59.35)	26 (63.41)
IASCs				0.569
Yes	27 (6.99)	15 (9.68)	3 (7.32)
No	359 (93.01)	140 (90.32)	38 (92.68)

IASCs: Intra-abdominal septic complications.