Roles of Wnt/β-catenin signaling pathway related microRNAs in esophageal cancer

Table 1 MicroRNA associated with Wnt pathway in esophageal carcinoma

MicroRNAs	Target genes	Molecular functions	Expression pattern	Interaction with Wnt signaling	Cancer phenotype	Ref.
MiR-1275	Wnt1	Receptor targeting Wnt protein	Up	Repress	Inhibition of radiosensitivity of ESCC cells	[32]
MiR-4261	DKK2	The proliferation, migration and invasion of esophageal cancer cells can be inhibited	Up	Repress	Involvement in tumor progression and poor prognosis of ESCC	[15]
MiR-106b-3p	ZNRF3	Promote epithelial-mesenchymal transition	Up	Activate	Promote cell proliferation and invasion	[16]
MiR-301a	Wnt1	Increased resistance to autophagy and radiation	Up	Repress	Inhibition of proliferation and migration of ESCC cells and enhancement of radiosensitivity	[17]
MiR-let-7a	LIN28	Transformation, matrix decomposition and angiogenesis	Down	Activate	Promoting invasion, metastasis and poor prognosis of ESCC	[21]
MiR-30a-3p/5p	Wnt2 and Fzd2	Gene transcription	Down	Activate	Promote the proliferation of ESCC cells	[22]
MiR-455-3p	DKK3/GSK3β/TCF7L1	Stem cell development	Up	Activate	Promoting chemotherapy resistance and invasiveness of ESCC	[24]
MiRNA-638	DACT3	Autophagy	Up	Activate	Promote autophagy and malignant phenotype of cancer cells	[38]
MiR-221	DKK2	Imbalance of signal transduction and chemoresistance target genes	Up	Activate	Mediating chemotherapy resistance of esophageal adenocarcinoma	[41]
MiR-200b	CDK2 and PAF	Apoptosis and cell cycle progression	Down	Repress	Induction of cell cycle arrest and inhibition of cell growth in ESCC	[26]
MiR-214	β-catenin mRNA3‘-UTR	Inhibit protein translation	Down	Repress	Inhibit cell growth and invasion	[27]
MiR-125b	SFRP4	The cause is unknown	Down	Activate	Promote the growth of ESCC cells	[29]
MiR-942	SFRP4/GSK3β/TLE1	Promote stem-cell-like characteristics	Up	Activate	Promoting tumor stem cell-like characteristics of ESCC	[43]

ESCC: Esophageal squamous cell carcinoma; DKK2: Dickkopf-related protein 2; ZNRF3: Zinc and ring finger 3; PAF: Platelet-activating factor; CDK2: Cyclin-dependent kinase 2; TLE1: Transducer-like enhancer of split 1; GSK3β: Glycogen synthase kinase-3β; SFRP: Secreted frizzled-related protein; DACT3: Dishevelled-associated antagonist of β-catenin 3.