Correlation between betatrophin/angiogenin-likeprotein3/lipoprotein lipase pathway and severity of coronary artery disease in Kazakh patients with coronary heart disease

Figure 3 Schematic diagram of betatrophin and angiogenin-likeprotein3 participating in lipid regulation. Betatrophin synthesized by the liver under the stimulation of feeding or insulin can promote the cleavage of angiogenin-likeprotein3 (ANGPTL3) to release the active N-terminal catalytic core domain (CCD) domain, which leads to a decrease in the inhibitory effect of ANGPTL3 on Lipoprotein lipase (LPL) activity and indirectly promotes LPL to participate in lipid metabolism. When triglyceride- derived fatty acids enter the adipocytes, some of them form lipid droplets, while the other part induces the increase of LPL synthesis in adipocytes, and enters the blood circulation to participate in lipid metabolism mediated by glycosylphosphatidylinositol high density lipoprotein binding protein 1. GPIHBP1: Glycosylphosphatidylinositol high density lipoprotein binding protein 1; HSPG: Heparan sulfate proteoglycan; CM: Chylomicrons; TG: Triglycerides.