Novel ABCB4 mutations in an infertile female with progressive familial intrahepatic cholestasis type 3: A case report

Figure 2 Pathological examination of liver biopsy specimens. A: The interstitial fibrous tissue in the portal area proliferates, and the fibrous septum is formed (Masson; original magnification × 100); B: The portal area was enlarged with moderate mixed inflammatory cell infiltration and mild interfacial inflammation (hematoxylin and eosin; original magnification × 100); C: Irregular arrangement of the epithelium of the small bile duct in the portal area (hematoxylin and eosin; original magnification × 200); D: Absence of small bile duct in part of the portal area (CK7; original magnification × 200); E: Multidrug resistance protein 3 (MDR3) protein staining decreased significantly (immunohistochemical staining; original magnification × 200); F: Liver biopsy specimens from a healthy person showing normal expression of the MDR3 protein (immunohistochemical staining; original magnification × 200).