Effects of bilirubin on perioperative myocardial infarction and its long-term prognosis in patients undergoing percutaneous coronary intervention

Table 3 Cox proportional hazard regression model: incidence of major adverse cardiac events

Variable	Univariate model		Multivariate model
	HR (95%CI)	P value	HR (95%CI)	P value
Age > 65 yr	1.199 (1.080, 1.332)	0.001	1.123 (1.001, 1.260)	0.048
Male	1.213 (0.921, 1.598)	0.170
BMI	1.005 (0.969, 1.042)	0.782
Current smoking	0.982 (0.733, 1.316)	0.905
Diabetes	1.135 (1.098, 1.173)	< 0.001	1.119 (1.079, 1.161)	< 0.001
Hypertension	1.122 (0.848, 1.484)	0.420
eGFR < 60 (mL/min/1.73 m2)	1.291 (0.936, 1.780)	0.120
LVEF	0.996 (0.984, 1.008)	0.540
Unstable angina	1.284 (1.003, 1.644)	0.048	1.381 (1.071, 1.781)	0.013
LDL-C > 1.8 mmol/L	1.160 (1.650, 1.264)	0.001	1.094 (0.996, 1.201)	0.060
Perioperative medications
ACEI/ARB	1.077 (0.825, 1.405)	0.586
Beta-blocker	1.044 (0.810, 1.345)	0.739
Calcium-channel blocker	1.197 (0.872, 1.644)	0.266
AHA/ACC classification B2/C	0.848 (0.638, 1.128)	0.258
Calcification	1.197 (0.872, 1.644)	0.266
Number of stents implanted	1.186 (1.031, 1.365)	0.017	1.171 (1.012, 1.354)	0.034
Total bilirubin
Tertile I	1 (ref)		1 (ref)
Tertile II	0.801 (0.604, 1.063)	0.125	0.837 (0.627, 1.119)	0.229
Tertile III	0.640 (0.469, 0.875)	0.005	0.667 (0.485, 0.918)	0.013

ACEI: Angiotensin-Converting Enzyme Inhibitors; AHA/ACC: American Heart Association/American College of Cardiology; ARB: Angiotensin Receptor Blocker; BMI: Body mass index; eGFR: Estimated glomerular filtration rate; FFR: Fractional flow reserve; IVUS: Intravascular ultrasound; LVEF: Left ventricular ejection fraction; MI: Myocardial infarction; OCT: Optical coherence tomography.