Effects of bilirubin on perioperative myocardial infarction and its long-term prognosis in patients undergoing percutaneous coronary intervention

Table 2 Factors affecting perioperative myocardial infarction in univariate and multivariate analysis

Variable	Univariate model		Multivariate model
	OR (95%CI)	P value	OR (95%CI)	P value
Age > 65 yr	1.428 (1.268, 1.607)	< 0.001	1.272 (1.110, 1.457)	0.001
Female	1.225 (1.084, 1.384)	0.001	1.200 (1.034, 1.393)	0.017
BMI	0.983 (0.966, 1.000)	0.052
Current smoking	0.832 (0.721, 0.959)	0.011	0.943 (0.797, 1.117)	0.499
Diabetes	1.134 (0.999, 1.287)	0.052
Hypertension	1.271 (1.120, 1.443)	< 0.001	1.054 (0.901, 1.233)	0.509
Prior stroke	1.181 (0.976, 1.428)	0.087
Prior MI	1.309 (1.108, 1.547)	0.002	1.200 (0.991, 1.454)	0.062
eGFR < 60 (mL/min/1.73 m2)	1.645 (1.400, 1.933)	< 0.001	1.369 (1.135, 1.651)	0.001
LVEF	0.975 (0.968, 0.982)	< 0.001	0.980 (0.972, 0.988)	< 0.001
Unstable angina	1.116 (0.996, 1.250)	0.059
Perioperative medications
ACEI/ARB	1.243 (1.107, 1.395)	< 0.001	1.112 (0.965, 1.281)	0.144
Beta-blocker	0.992 (0.886, 1.112)	0.896
Calcium-channel blocker	1.067 (0.948, 1.201)	0.280
LDL-C > 1.8 mmol/L	0.930 (0.808, 1.070)	0.311
AHA/ACC classification B2/C	1.167 (1.040, 1.311)	0.009	1.363 (1.192, 1.558)	< 0.001
Calcification	1.767 (1.514, 2.063)	< 0.001	1.303 (1.091, 1.556)	0.004
FFR/IVUS/OCT	1.391 (1.178, 1.642)	< 0.001	1.275 (1.056, 1.539)	0.011
Number of implanted stents	1.868 (1.741, 2.006)	< 0.001	1.882 (1.738, 2.038)	< 0.001
Mean stent size > 2.5 mm	1.117 (0.917, 1.362)	0.272
Balloon pre-dilation	1.116 (0.937, 1.330)	0.217
Balloon post-dilation	1.330 (0.926, 1.912)	0.123
Total bilirubin
Tertile I	1 (ref)		1 (ref)
Tertile II	0.800 (0.698, 0.918)	0.001	0.854 (0.739, 0.987)	0.032
Tertile III	0.786 (0.685, 0.902)	0.001	0.846 (0.735, 0.975)	0.021

ACEI: Angiotensin-Converting Enzyme Inhibitors; AHA/ACC: American Heart Association/American College of Cardiology; ARB: Angiotensin Receptor Blocker; BMI: Body mass index; eGFR: Estimated glomerular filtration rate; FFR: Fractional flow reserve; IVUS: Intravascular ultrasound; LVEF: Left ventricular ejection fraction; MI: Myocardial infarction; OCT: Optical coherence tomography.