Effects of bilirubin on perioperative myocardial infarction and its long-term prognosis in patients undergoing percutaneous coronary intervention

Table 1 Baseline demographic, clinical characteristics and angiographic characteristics of the study population (mean ± SD)

Variable	Tertile I < 10.2 μmol/L, n = 3430	Tertile II 10.2-14.4 μmol/L, n = 3405	Tertile III > 14.4 μmol/L, n = 3401	P value (All)	Tertile I vs Tertile II	Tertile I vs Tertile III	Tertile II vs Tertile III
Age (years)	66.9 ± 10.4	66.3 ± 10.3	65.6 ± 10.0	< 0.001	0.020	< 0.001	0.006
Female, n (%)	1232 (36.0)	1017 (29.9)	676 (19.9)	< 0.001	< 0.001	< 0.001	< 0.001
BMI (kg/m2)	24.6 ± 4.9	24.9 ± 11.2	24.9 ± 10.1	0.314	0.063	0.091	0.651
Current smoking, n (%)	774 (22.6)	731 (21.5)	735 (21.6)	0.491	0.401	0.288	0.821
Diabetes, n (%)	1015 (29.6)	848 (24.9)	782 (23.0)	< 0.001	< 0.001	< 0.001	0.028
Hypertension, n (%)	2413 (70.4)	2327 (68.3)	2276 (66.9)	0.008	0.021	< 0.001	0.122
Hyperlipidemia, n (%)	532 (15.5)	557 (16.4)	522 (15.3)	0.470	0.449	0.726	0.266
Prior stroke, n (%)	353 (10.3)	300 (8.8)	253 (7.4)	< 0.001	0.037	< 0.001	0.110
eGFR < 60 (mL/min/1.73 m2), n (%)	488 (14.2)	345 (10.1)	269 (7.9)	< 0.001	< 0.001	< 0.001	< 0.001
LVEF (%)	66.8 ± 8.0	67.2 ± 7.8	67.0 ± 9.0	0.096	0.031	0.575	0.008
Prior MI, n (%)	395 (11.5)	360 (10.6)	399 (11.7)	0.271	0.054	0.861	0.071
Prior PCI, n (%)	876 (25.5)	800 (23.5)	806 (23.7)	0.094	0.052	0.056	0.978
Unstable angina, n (%)	1850 (54.0)	1740 (51.1)	1708 (50.3)	0.006	0.002	< 0.001	0.528
Perioperative medications, n (%)
ACEI/ARB	1979 (57.7)	1916 (56.3)	1825 (53.7)	0.003	0.613	< 0.001	0.021
Beta-blocker	1746 (50.9)	1746 (51.3)	1691 (49.7)	0.407	0.835	0.129	0.082
Calcium-channel blocker	1270 (37.0)	190 (34.9)	1114 (32.8)	0.001	0.004	< 0.001	0.034
LDL-C (mmol/L)	2.05 ± 0.88	2.09 ± 0.86	2.04 ± 0.86	0.053	0.117	0.843	0.076
Lesions in vessels, n (%)
Left main	197 (5.7)	186 (5.5)	180 (5.3)	0.711	0.613	0.578	0.959
Left anterior descending	1828 (53.3)	1848 (54.3)	1837 (54.0)	0.702	0.187	0.321	0.926
Left circumflex	579 (16.9)	524 (15.4)	578 (17.0)	0.136	0.068	0.902	0.051
Right coronary artery	983 (28.7)	994 (29.2)	955 (28.1)	0.597	0.960	0.196	0.184
AHA/ACC classification B2/C, n (%)	1228 (35.8)	1256 (36.8)	1356 (39.9)	0.002	0.487	< 0.001	0.006
Calcification, n (%)	406 (11.8)	391 (11.5)	390 (11.5)	0.864	0.204	0.485	0.567
FFR/IVUS/OCT, n (%)	357 (10.4)	372 (10.9)	402 (11.8)	0.170	0.496	0.050	0.210
Number of implanted stents, median (IQR)	1 (1-2)	1 (1-2)	1 (1-2)	< 0.001	0.005	0.005	0.133
Mean stent size > 2.5 mm, n (%)	3107 (90.6)	3077 (90.4)	3056 (89.9)	0.606	0.755	0.282	0.464
Balloon pre-dilation, n (%)	3031 (88.4)	2970 (87.2)	2921 (85.9)	0.009	0.039	0.001	0.183
Balloon post-dilation, n (%)	3175 (92.6)	3145 (92.4)	3156 (92.8)	0.793	0.999	0.828	0.827

Data are presented as n or %. ACEI: Angiotensin-Converting Enzyme Inhibitors; AHA/ACC: American Heart Association/American College of Cardiology; ARB: Angiotensin Receptor Blocker; BMI: Body mass index; eGFR: Estimated glomerular filtration rate; FFR: Fractional flow reserve; IVUS: Intravascular ultrasound; LVEF: Left ventricular ejection fraction; MI: Myocardial infarction; OCT: Optical coherence tomography.