Intensive vs non-intensive statin pretreatment before percutaneous coronary intervention in Chinese patients: A meta-analysis of randomized controlled trials

Table 1 Characteristics of the included studies

Ref.	Sample size (intensive/non-intensive statin)	Clinical presentation	Statin medication history	Primary/elective PCI	Statin regimen before PCI	Statin regimen after PCI	Follow-up (d)	Outcome indicators
								Effectiveness	Safety
Liu et al[10], 2016	616 (307/309)	Stable angina, ACS	Statin-naïve or atorvastatin ≤ 20mg/d, or equivalent dose statin	Elective PCI	Atorvastatin 80 mg 12 h before PCI vs no statin pretreatment	40 mg/d vs 20 mg/d	30	MACE, non-fatal MI	Myalgia/myasthenia*
	182 (93/89)	STEMI	Statin-naïve or atorvastatin ≤ 20mg/d, or equivalent dose statin	Primary PCI	Atorvastatin 80 mg just before primary PCI vs no statin pretreatment	40 mg/d vs 20 mg/d	90		ALT
Jiao et al[11], 2015	72 (33/39)	NSTE-ACS	Not mentioned	Elective PCI	Rosuvastatin 20 mg 12 h before PCI + 20 mg just before PCI vs no statin pretreatment	10 mg/d	30	MACE, cardiac death, non-fatal MI, TVR
Jiao et al[12], 2015	126 (62/64)	NSTE-ACS	Not mentioned	Elective PCI	Rosuvastatin 20 mg 12 h before PCI + 20 mg just before PCI vs no statin pretreatment	10 mg/d	30		Myalgia/myasthenia
Zheng et al[7], 2015	1202 (573/629)	Stable angina, NSTE-ACS	Statin-naïve or atorvastatin ≤ 20mg/d or equivalent dose statin	Elective PCI	Atorvastatin 80 mg at night before PCI for 2 d vs atorvastatin ≤ 20 mg or equivalent dose statin at night before PCI	40 mg/d vs ≤ 20 mg/d or equivalent dose statin	30	MACE, cardiac death, non-fatal MI, TVR
Xie et al[13], 2014	159 (79/80)	NSTE-ACS	Statin-naïve	Elective PCI	Rosuvastatin 20 mg 12 h before PCI + 20 mg 2 h before PCI vs no statin pretreatment	10 mg/d	30	MACE, cardiac death, non-fatal MI, TVR
Luo et al[14], 2013	67 (31/36)	NSTE-ACS	Statin-naïve	Elective PCI	Rosuvastatin 20 mg 12 h before PCI + 20 mg 2 h before PCI vs no statin pretreatment	10 mg/d	30	MACE, cardiac death, non-fatal MI, TVR
Wang et al[15], 2013	125 (62/63)	NSTE-ACS	Statin-naïve	Elective PCI	Rosuvastatin 20 mg 2-4 h before PCI vs placebo 2-4 h before PCI	10 mg/d	30	MACE, cardiac death, non-fatal MI, TVR
Li et al[16], 2013	215 (106/109)	Stable angina	Regular statin for at least 3 mo	Elective PCI	Atorvastatin 80 mg 12 h before PCI vs 20 mg 12 h before PCI	20 mg/d	30	MACE, cardiac death, non-fatal MI, TVR
Gao et al[17], 2012	117 (59/58)	NSTE-ACS	Statin-naïve	Elective PCI	Rosuvastatin 20 mg 12 h before PCI + 10 mg 2 h before PCI vs placebo 12 h before PCI + 2 h before PCI	10 mg/d	90	MACE, cardiac death, non-fatal MI, TVR
Li et al[18], 2012	161 (78/83)	STEMI	Statin-naïve	Primary PCI	Atorvastatin 80 mg 1.5 h before PCI vs placebo 1.5 h before PCI	40 mg/d	30		ALT
Yu et al[19], 2011	81 (41/40)	NSTE-ACS	Statin-naïve	Elective PCI	Atorvastatin 80 mg 12 h before PCI + 40 mg 2 h before PCI vs placebo 12 h before PCI + 2 h before PCI	20 mg/d	30	MACE, cardiac death, non-fatal MI, TVR

PCI: Percutaneous coronary intervention; MACE: Major adverse cardiac events; MI: Myocardial infarction; NSTE-ACS: Non-ST segment elevation acute coronary syndrome; STEMI: ST segment elevation myocardial infarction; TVR: Target vessel revascularization; ALT: Alanine aminotransferase; ACS: Acute coronary syndrome.