Effect of prior malignancy on the prognosis of gastric cancer and somatic mutation

Table 4 Multivariable Cox regression analysis of survival in gastric cancer patients stratified by age, stage, and timing of prior cancer (prior cancer vs < none)

Characteristics	All-cause survival (CI)	P value	Gastric cancer-specific survival (CI)	P value
Age (yr)
< 65	1.08 (1.00, 1.18)	0.064	0.77 (0.69, 0.85)	< 0.001
≥ 65	1.00 (0.96, 1.04)	0.843	0.83 (0.79, 0.87)	< 0.001
Stage
Localized	1.10 (1.02, 1.19)	0.012	0.82 (0.74, 0.91)	< 0.001
Regional	0.99 (0.92, 1.06)	0.777	0.84 (0.78, 0.92)	< 0.001
Distant	0.92 (0.87, 0.98)	0.014	0.79 (0.73, 0.85)	< 0.001
Timing of prior cancer
< 5	1.03 (0.98, 1.09)	0.275	0.77 (0.72, 0.82)	< 0.001
5-10	0.98 (0.92, 1.04)	0.525	0.84 (0.78, 0.90)	< 0.001
≥ 10	1.01 (0.94, 1.08)	0.811	0.88 (0.81, 0.95)	0.001

Adjusted for age, race, sex, marital status, grade, stage, size, radiation, surgery, chemotherapy. AHR: Adjusted hazard ratio; CI: Confidence interval.