Effect of prior malignancy on the prognosis of gastric cancer and somatic mutation

Table 3 Multivariable Cox regression analysis of survival in patients with gastric cancer¹

Characteristics	All-cause adjusted HR	P value	Cancer-specific adjusted HR	P value
Age (yr; vs < 65)
≥ 65	1.32 (1.28, 1.35)	< 0.001	1.25 (1.22, 1.29)	< 0.001
Sex (vs male)
Female	0.93 (0.91, 0.96)	< 0.001	0.95 (0.92, 0.98)	< 0.001
Race (vs white)
Black	1.09 (1.05, 1.13)	< 0.001	1.07 (1.03, 1.12)	< 0.001
AI/AN	1.14 (1.01, 1.29)	0.033	1.16 (1.02, 1.32)	0.023
AP	0.79 (0.76, 0.82)	< 0.001	0.79 (0.76, 0.82)	< 0.001
Marital status (vs married)
Unmarried	1.14 (1.12, 1.17)	< 0.001	1.11 (1.08, 1.14)	< 0.001
Gastric cancer site (vs cardia and fundus)
Body of stomach	0.96 (0.92, 0.99)	0.013	0.93 (0.90, 0.97)	< 0.001
Antrum and Pylorus	0.99 (0.96, 1.03)	0.727	0.97 (0.93, 1.01)	0.114
Lymph nodes examined (vs no examined)
1-15	0.73 (0.69, 0.77)	< 0.001	0.72 (0.68, 0.77)	< 0.001
≥ 16	0.65 (0.61, 0.68)	< 0.001	0.66 (0.62, 0.71)	< 0.001
Prior history of cancer (vs none)
Yes	1.01 (0.97, 1.05)	0.644	0.82 (0.78, 0.85)	< 0.001
SEER stage (vs localized)
Regional	2.34 (2.26, 2.44)	< 0.001	2.83 (2.70, 2.96)	< 0.001
Distant	3.43 (3.31, 3.57)	< 0.001	4.35 (4.16, 4.54)	< 0.001
Grade (vs G1)
G2	1.19 (1.10, 1.28)	< 0.001	1.27 (1.16, 1.38)	< 0.001
G3	1.56 (1.45, 1.67)	< 0.001	1.75 (1.61, 1.91)	< 0.001
G4	1.60 (1.43, 1.79)	< 0.001	1.85 (1.63, 2.09)	< 0.001
Surgery (vs none)
Yes	0.45 (0.43, 0.48)	< 0.001	0.44 (0.42, 0.47)	< 0.001
Radiation (vs none)
Radiation	0.92 (0.89, 0.95)	0.007	0.92 (0.89, 0.96)	< 0.001
Chemotherapy (vs none)
Chemotherapy	0.52 (0.51, 0.54)	< 0.001	0.53 (0.51, 0.55)	< 0.001

¹Adjusted for age, race, sex, marital status, grade, stage, size, radiation, surgery, chemotherapy. AI/AN: American Indian/Alaska Native; AP: Asian or Pacific Islander; CI: Confidence interval; G1: Well-differentiated; G2: Moderately differentiated; G3: Poorly differentiated; G4: Undifferentiated; HR: Hazard ratio.