Langerhans cell histiocytosis presenting as an isolated brain tumour: A case report

Table 1 Summary of 16 cases with brain parenchymal langerhans cell histiocytosis with imaging data

Ref.	Age/sex	Diameter (cm)1	Location (Lobe)	MRI Finding			18F-FDG PET/CT finding
				T1WI	T2WI	T1WI with contrast
Caresio et al[20], 1991	29/Male	3.0	Right temporal lobe	Hypointense	Hyperintense	Ringlike enhancement	NA
Itoh et al[21], 1992	7/Male	NA	Right frontal lobe	Hypo-/iso-intense	Hyperintense	Intense enhancement	NA
Bogaert et al[22], 1994	40/Female	NA	Left parietal lobe	Hypointense	Hyperintense	Intense enhancement	NA
Vital et al[23], 1996	32/Female	NA	Right insula lobe	NA	Hyperintense	Intense enhancement	NA
Grant et al[24], 1999	20/Male	3.5	Right temporal lobe	NA	NA	Intense enhancement	NA
Katati et al[25], 2002	36/Male	NA	Left temporal lobe	Hypointense	NA	Intense enhancement	NA
Cagli et al[9], 2004	24/Male	1.5	Left temporal lobe	Hypointense	NA	Intense enhancement	NA
Yamaguchi et al[26], 2004	2/Male	NA	Multiple lesions/bilateral frontal and temporal lobes	NA	NA	Intense enhancement	NA
Rodríguez-Pereira et al[10], 2005	30/Male	5.0	Left frontal lobe	NA	NA	Gyral enhancement	NA
Rodríguez-Pereira et al[10], 2005	65/Male	2.5	Left parietal lobe	NA	NA	Peripheral enhancement	NA
Dieter[27], 2017	4/Male	2.01	Multiple lesions, right frontal, and parietal lobe	Iso-/hyper-intense	Hypointense	Uniform enhancement	NA
Cai et al[6], 2014	23/Male	4.1	Right frontal lobe	Hypo-/iso-intense	Iso-/hyper-intense	Moderate to intense homogeneous enhancement	NA
Dardis et al[28], 2015	64/Male	NA	Multiple lesions, left frontal and right temporal lobe, and brainstem	NA	Hyperintense	Patchy enhancement	NA
Kim et al[7], 2018	36/Male	3.0	Right frontal lobe	Isointense	Hyperintense	Heterogeneous enhancement	NA
Bärtschi et al[8], 2019	42/Male	NA	Right insular lobe	NA	Hyperintense	Intense enhancement	NA
Current case	47/Male	3.6	Left frontal lobe	Hypointense	Hyperintensity with hypointense areas	Heterogeneous enhancement	Lesion SUVmax 9.5 and contralateral SUVmax 8.1

¹The largest lesion.

NA: Not available; PET: Positron emission tomography; CT: Computed tomography; T1WI: T1-weighted images; T2WI: T2-weighted images; MRI: Magnetic resonance imaging.