Hepatic sinusoidal obstruction syndrome induced by tacrolimus following liver transplantation: Three case reports

Table 1 Clinical characteristics of three presented cases during the disease course

No.	Age (yr)/sex	Clinical course	POD (d)	Ascites (mL/d)	TBIL (μmol/L)	ALT (U/mL)		AST (U/mL)		GGT (U/mL)	ALP (U/mL)	Scr (μmol/L)	BUN (mmol/L)	GFR (mL/min/L)
1	43/M	Diagnosis of HSOS	13	4600	28.2	97.6	173.2		244.6		240	231	25.61	26.92
		Tac → Siro	69	3250	48.4	273.6	210.7		113.1		153	379.9	40.11	15.16
		Discharged	74	2150	23.5	12.2	25.8		72.6		123	679.1	53.97	7.76
2	56/M	Diagnosis of HSOS	50	1200	28.2	48.7	54.3		89.2		122	227.7	13.15	25.94
		Tac → CsA + Siro	59	2480	20.4	39.2	38.3		50.7		94	702	18.33	7.08
		Resolution	87	30	12.7	22.3	27.6		79.2		121	72	3.56	97.96
3	57/M	Diagnosis of HSOS	15	850	22.5	143.6	47.3		129.9		159	111.5	12.28	58.93
		Tac → Siro	23	400	26.6	37.1	17.7		59.8		102	176.1	25.11	34.77
		Resolution	37	50	13.6	37.2	27.3		26.8		81	66.9	10	106.25

ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BUN: Blood urea nitrogen; GFR: Glomerular filtration rate; GGT: Gamma-glutamyl transpeptidase; HSOS: Hepatic sinusoidal obstruction syndrome; POD: Postoperative day; Scr: Serum creatinine; Siro: Sirolimus; Tac: Tacrolimus; TBIL: Total bilirubin.