Risk of critical limb ischemia in long-term uterine cancer survivors: A population-based study

Table 3 Crude and adjusted hazard ratios for the occurrence of critical limb ischemia in the older group using a stratified Cox model with withdrawal as a competing risk

	Crude HR (95%CI)		P value	Adjusted HR1 (95% CI)		P value
Group (controls)	1		0.503	1
UC survivors2	1.17	(0.74-1.85)		1.29	(0.80-2.07)	0.299
Surgery alone3				0.93	(0.47-1.84)	0.832
Surgery + RT3				2.12	(1.13-3.95)	0.019
Morbid obesity	6.00	(2.08-17.29)	0.001	5.55	(1.82-16.94)	0.003
Smoking	0.92	(0.52-1.62)	0.769
Comorbidity
Diabetes	1.67	(1.08-2.59)	0.021
Hypertension	2.24	(1.36-3.68)	0.002	2.06	(1.24-3.43)	0.005
Hyperlipidemia	1.59	(0.98-2.57)	0.062
Chronic kidney disease	0.800	(0.11-5.63)	0.823
HRT
0 d	1			1
1-30 d	0.68	(0.38-1.24)	0.208	0.60	(1.06-7.91)	0.100
30-180 d	1.01	(0.47-2.15)	0.979	0.82	(1.62-19.65)	0.615
> 180 d	5.24	(1.81-15.23)	0.002	4.54	(1.38-14.91)	0.013

¹Adjusted hazard ratios and P values were obtained from a multiple stratified Cox model, which included treatment modality and significant explanatory variables only.

²All UC survivors, regardless of treatment modality.

³Treatment modalities (surgery alone and surgery with RT) were examined in the Cox model.

UC: Uterine cancer; RT: Radiotherapy; HRT: Hormone replacement therapy; HR: Hazard ratio; CI: Confidence interval; CLI: Critical limb ischemia.