Risk of critical limb ischemia in long-term uterine cancer survivors: A population-based study

Table 2 Crude and adjusted hazard ratios for the occurrence of critical limb ischemia in the younger group using a stratified Cox model with withdrawal as a competing risk

	Crude HR (95%CI)		P value	Adjusted HR1 (95%CI)		P value
Group (controls)	1		0.150	1		0.395
UC survivors2	1.68	(0.83-3.43)		0.66	(0.25-1.72)
Surgery alone3				0.75	(0.25-2.22)	0.601
Surgery + RT3				0.34	(0.10-1.15)	0.083
Morbid obesity	1.36	(0.35-5.37)	0.659
Smoking	1.83	(0.62-5.35)	0.271
Diabetes	4.49	(1.76-11.44)	0.002	2.93	(1.09-7.92)	0.033
Hypertension	2.89	(1.33-6.27)	0.007	3.61	(1.43-9.08)	0.006
Hyperlipidemia	3.12	(1.31-7.46)	0.010
Chronic kidney disease	4.00	(0.40-39.83)	0.237
HRT
0 d	1			1
1-30 d	1.98	(0.82-4.75)	0.127	2.89	(1.06-7.91)	0.038
30-180 d	3.67	(1.16-11.58)	0.027	5.65	(1.62-19.65)	0.006
> 180 d	22.36	(3.43-145.80)	0.001	25.75	(4.72-155.24)	< 0.001

¹Adjusted HRs and P values were obtained from a multiple stratified Cox model, which included treatment modality and significant explanatory variables only.

²All UC survivors, regardless of treatment modality.

³Treatment modalities (surgery alone and surgery with RT) were examined in the Cox model.

UC: Uterine cancer; RT: Radiotherapy; HRT: Hormone replacement therapy; HR: Hazard ratio; CI: Confidence interval; CLI: Critical limb ischemia.