Risk of critical limb ischemia in long-term uterine cancer survivors: A population-based study

Table 1 Characteristics of uterine cancer survivors and matched normal controls

Characteristic	UC survivors, onset age < 50 years (n = 894)	Normal controls (n = 3576)	P value	UC survivor, onset age 50 years (n = 995)	Normal controls (n = 3980)	P value
Age at index date (yr)	48.00 ± 5.63	47.82 ± 5.74		63.09 ± 6.83	63.23 ± 7.25
25-40	88 (9.84)	352 (9.84)	1.00			1.00
40-45	121 (13.53)	484 (13.53)
45-50	251 (28.08)	1004 (28.08)
50-55	434 (48.55)	1736 (48.55)
55-60				391 (39.30)	1564 (39.30)
60-65				267 (26.83)	1068 (26.83)
65-70				155 (15.58)	620 (15.58)
> 70				182 (18.29)	728 (18.29)
Urbanization
1 (least urbanized)	174 (19.46)	696 (19.46)	0.768	229 (23.01)	996 (23.01)	1.00
2	216 (24.16)	867 (24.24)		223 (22.41)	1184 (22.41)
3	300 (33.56)	1197 (33.47)		296 (29.75)	892 (29.75)
4	204 (22.82)	816 (22.82)		247 (24.82)	908 (24.82)
Income-related insurance payment
1 (lowest)	449 (50.22)	1793 (50.14)	0.600	665 (66.83)	2660 (66.83)	1.00
2	214 (23.94)	856 (23.94)		153 (15.38)	612 (15.38)
3	146 (16.33)	587 (16.41)		132 (13.27)	528 (13.27)
4 (highest)	85 (9.51)	340 (9.51)		45 (4.52)	180 (4.52)
Morbid obesity1	44 (4.92)	111 (3.10)	0.010	18 (1.81)	123 (3.09)	0.031
Smoking-related diseases2	39 (4.36)	351 (9.82)	< 0.001	73 (7.33)	737 (18.52)	< 0.001
HRT3			0.033			0.108
0	548 (61.30)	2200 (61.52)		663 (66.63)	(69.87)
1-30 d	208 (23.27)	1158 (32.38)		229 (23.02)	774 (19.45)
31-180 d	113 (12.64)	192 (5.37)		90 (9.05)	350 (8.79)
> 180 d	25 (2.80)	26 (0.73)		13 (1.31)	75 (1.88)
Comorbidity
Hypertension	244 (27.39)	506 (14.15)	< 0.001	473 (47.54)	1779 (44.70)	0.094
Diabetes	164 (18.34)	198 (5.54)	< 0.001	236 (23.72)	816 (20.50)	0.026
Atrial fibrillation	5 (0.56)	11 (0.31)	0.268	12 (1.21)	65 (1.63)	0.312
Hyperlipidemia	95 (10.63)	210 (5.87)	< 0.001	179 (17.99)	750 (18.84)	0.532
Chronic kidney disease	7 (0.78)	15 (0.42)	0.173	11 (1.11)	35 (0.88)	0.511
CLI	8 (0.89)	19 (0.53)		19 (1.91)	66 (1.66)
Mean follow-up after index date (yr)	4.515	4.535		4.377	4.358
Incidence per 100000 person-years4	198.21	117.17	0.212	436.25	380.54	0.599
Treatment modality
Surgery alone	727 (81.32)			694 (69.75)
Surgery + RT	167 (18.68)			301 (30.25)

¹Morbid obesity (ICD-9 code: 278, 278.00, 278.01, and V778).

²Smoking related diagnoses (ICD-9 code: 305.1, 491.2, 492.8, 496, 523.6, 959.84, 649.0, and V15.82).

³Number of days of taking hormone replacement therapy (HRT) per year during the follow-up period. HRT was identified according to the Anatomical Therapeutic Chemical classification system and included estrogen only (G03C) and an estrogen-progesterone combination (G03F).

⁴Incidence per 100000 person-years. Data are presented as n (%) or mean ± SD.

UC survivors and the comparison group were matched by 5-year age group, sex, urbanization level, and income-related insurance payment. All P values were obtained from generalized estimating equations models. UC: Uterine cancer; RT: Radiotherapy; HRT: Hormone replacement therapy; CLI: Critical limb ischemia.