Lipoprotein (a) variability is associated with mean follow-up C-reactive protein in patients with coronary artery disease following percutaneous coronary intervention

Table 4 Association of lp (a) variability independent of the mean with average C-reactive protein level in linear regression

	Univariable analysisb		Multivariable analysis
	β coefficient (95%CI)	P value	β coefficient (95%CI)	P value
Lp (a) VIM	1.692 (1.026, 2.359)	< 0.001	1.648 (0.977, 2.320)	< 0.001a
Average lp (a) level, mg/dL	0.002 (0.000, 0.004)	0.059	0.003 (0.001, 0.005)	0.013a
Age in yr	0.026 (0.020, 0.031)	< 0.001	0.031 (0.025, 0.037)	< 0.001a
Male	-0.017 (-0.152, 0.119)	0.811
Diabetes	0.312 (0.173, 0.451)	< 0.001	0.201 (0.062, 0.340)	0.005a
Hypertension	0.314 (0.188, 0.440)	< 0.001	0.124 (-0.006, 0.254)	0.062
BMI, kg/m2	0.029 (0.009, 0.049)	0.004	0.028 (0.008, 0.048)	0.006a
Current smoking	0.104 (-0.034, 0.242)	0.139
Average LDL-C level, mmol/L	0.215 (0.117, 0.312)	< 0.001	0.200 (0.099, 0.301)	< 0.001a
Average WBC count, × 109/L	0.256 (0.207, 0.304)	< 0.001	0.261 (0.213, 0.309)	< 0.001a
Previous PCI	0.041 (-0.208, 0.291)	0.744
Statin	-0.662 (-1.186, 0.139)	-0.013	-0.655 (-1.177, 0.132)	-0.014a
Ezetimibe	-0.202 (-0.365, 0.039)	-0.015	-0.331 (-0.494, -0.167)	< 0.001a

^aP < 0.05.

^bPredictors with P < 0.10 in univariable linear regression analysis were entered into the subsequent multivariable linear regression analysis. BMI: Body mass index; CI: Confidence interval; CRP: C-reactive protein; LDL-C: Low density lipoprotein cholesterol; Lp (a): Lipoprotein (a); PCI: Percutaneous coronary intervention; VIM: Variability independent of the mean; WBC: White blood cell.