Observational Study
Copyright ©The Author(s) 2022.
World J Clin Cases. Dec 16, 2022; 10(35): 12909-12919
Published online Dec 16, 2022. doi: 10.12998/wjcc.v10.i35.12909
Table 1 Baseline characteristics
Follow-up lp (a) CV
Parameter
Overall, n = 2712
< 0.22, n = 1388
≥ 0.22, n = 1324
P value
Demographics
Age, yr64.0 (58.0, 72.0)64.0 (58.0, 72.0)64.0 (57.0, 72.0)0.593
Male, n (%)1957 (72.2)982 (70.7)975 (73.6)0.102
BMI, kg/m224.7 (22.7, 26.1)24.6 (22.6, 26.1)24.7 (22.8, 26.2)0.191
Current smoking, n (%)710 (26.2)337 (24.3)373 (28.2)0.024a
Diabetes, n (%)692 (25.5)327 (23.6)365 (27.6)0.019a
Hypertension, n (%)1727 (63.7)869 (62.6)858 (64.8)0.251
Previous PCI, n (%)172 (6.3)92 (6.6)80 (6.0)0.584
Laboratory measurements
Average TC level, mmol/L3.67 (3.23, 4.18)3.67 (3.24, 4.16)3.67 (3.21, 4.19)0.737
Average LDL-C level, mmol/L1.80 (1.50, 2.18)1.80 (1.49, 2.17)1.79 (1.50, 2.18)0.968
Average HDL-C level, mmol/L1.00 (0.86, 1.18)1.03 (0.88, 1.20)0.98 (0.84, 1.15)< 0.001a
Average TG level, mmol/L1.34 (1.04, 1.83)1.32 (1.02, 1.75)1.37 (1.06, 1.91)0.002a
Average CRP level, mg/L1.52 (0.80, 2.83)1.40 (0.72, 2.60)1.65 (0.87, 3.00)< 0.001a
Average WBC level, × 109/L6.38 (5.51, 7.25)6.30 (5.46, 7.25)6.43 (5.55, 7.26)0.089
Average lp (a) level, mg/dL14.00 (7.32, 34.90)16.70 (7.16, 45.81)12.52 (7.36, 25.48)< 0.001a
Lp (a) SD3.38 (1.61, 7.49)2.19 (0.95, 5.40)4.55 (2.61, 9.16)< 0.001a
Lp (a) CV0.22 (0.14, 0.32)0.14 (0.10, 0.18)0.32 (0.26, 0.43)< 0.001a
Lp (a) VIM0.17 (0.13, 0.23)0.13 (0.10, 0.15)0.24 (0.20, 0.29)< 0.001a
Medication, n (%)
Statin2675 (98.6)1379 (99.4)1296 (97.9)0.002a
Ezetimibe451 (16.6)218 (15.7)233 (17.6)0.204
ACEI or ARB1588 (58.6)776 (55.9)812 (61.3)0.005a
Beta blocker1639 (60.4)823 (59.3)816 (61.6)0.228
aP < 0.05. Data are presented as the median (interquartile range) or numbers (proportions). ACEI: Angiotensin-converting enzyme inhibitor; ARB: Angiotensin receptor antagonist; BMI: Body mass index; CRP: C-reactive protein; CV: Coefficient of variation; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; Lp (a): indicates lipoprotein (a); PCI: Percutaneous coronary intervention; SD: Standard deviation; TC: Total cholesterol; TG: Triglyceride; VIM: Variability independent of the mean; WBC: White blood cell.