Coptis, Pinellia, and Scutellaria as a promising new drug combination for treatment of Helicobacter pylori infection

Figure 2 Coptis, Pinellia, and Scutellaria inhibit the inflammatory reaction. A: Rapid urease test (RUT) and Warthin-Starry staining in mouse models of Helicobacter pylori (H. pylori)-associated gastritis; B: Effect of Coptis, Pinellia, and Scutellaria (CPS) on H. pylori infection. RUTs confirmed that the efficacy in the CPS and quadruple therapy groups was equal; C: Hematoxylin and eosin staining (200 ×); D and E: Enzyme-Linked Immunosorbnent Assay analysis of the serum levels of tumor necrosis factor-α and interleukin-1β in HAG mice. n = 7 per group or 9 per group (Vehicle, quadruple therapy, and CPS). Data are represented as the mean ± SD. RUT: Rapid urease test; HAG: Helicobacter pylori-associated gastritis; CPS: Coptis, Pinellia, and Scutellaria; NC: Negative control; QT: Quadruple therapy; IL-1β: Interleukin-1β; TNF-α: Tumor necrosis factor-α.