Long survival after immunotherapy plus paclitaxel in advanced intrahepatic cholangiocarcinoma: A case report and review of literature

Table 2 Immunomodulatory effects of chemotherapeutic agents

	Immunogenic cell death	PD-L1 ↑	MDSC ↓	Treg ↓	M2↓	MHC class I ↑	Dendritic cells mature	T-cell effectors ↑
Gemcitabine[39-41]	×	√	√	√	×	√	√	√
Platinum[42-45]	?	√	√	√	×	√	√	√
Paclitaxel[44,46-49]	√	√	√	√	√	√	√	√
Fluorouracil[50-53]	√	√	√	√	√	√	√	?

↑: Increase; ↓: Decrease; ?: Unsure; √: Modulate mechanism; ×: Does not modulate mechanism; MDSC: Myeloid derived suppressor cell; MHC: Major histocompatibility complex; PD-L1: Programmed death ligand 1; M2: Tumor-associated macrophage type 2; Treg: T-regulatory cell.