Endothelial injury and inflammation in patients with hyperuricemic nephropathy at chronic kidney disease stages 1-2 and 3-4

Table 3 Chronic kidney disease multivariate logistic regression analysis of staging and markers of endothelial injury and inflammation levels

Makers (plasm or urine)	B	Wald	Exp(B)	95%CI	Sig
Plasm heparan sulfate (pg/mL)	0.004	5.845	1.004	1.001-1.008	0.016a
Plasm endocan (pg/mL)	< 0.001	< 0.001	1.000	0.987-1.014	0.987
Plasm Ox-LDL (ng/mL)	-0.214	0.606	0.807	0.471-1.384	0.436
Plasm E-selectin (pg/mL)	0.002	0.644	1.002	0.997-1.007	0.422
Plasm slCAM1 (ng/mL)	2.178	6.952	8.831	1.749-44.588	0.008b
Plasm L-PGDS (ng/mL)	0.033	0.002	1.034	0.195-5.490	0.969
Plasm IL-1β (pg/mL)	-0.046	0.952	0.955	0.870-1.048	0.329
Plasm IL-6 (pg/mL)	-0.041	0.421	0.960	0.848-1.087	0.516
Urine IL-1β (pg/mL)	-0.010	0.016	0.990	0.847-1.157	0.901
Urine IL-6 (pg/mL)	0.046	0.126	1.047	0.813-1.348	0.723

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

CKD: Chronic kidney disease; Ox-LDL: Oxidized low density lipoprotein; slCAM1: Soluble intercellular adhesion molecule-1; L-PGDS: Lipocalin-type prostaglandin D synthase; IL: Interleukin; B: Partial regression coefficient; Wald: χ² value; Exp(B): Odds ratio; CI: Confidence interval; Sig: Significance.