Endothelial injury and inflammation in patients with hyperuricemic nephropathy at chronic kidney disease stages 1-2 and 3-4

Table 1 General data of patients in stages chronic kidney disease 1-2 and chronic kidney 3-4

Items		CKD 1-2 (n = 49)	CKD 3-4 (n = 31)	t/Z/χ2	P value
Age (yr)		42 (35-52)	66 (61-69)	6.514	< 0.001c
Sex	Male	48 (98.0%)	29 (93.5%)	1.023	0.312
	Female	1 (2.0%)	2 (6.5%)
Course of gout (mo)		45.7 (14.8-80.55)	81.3 (39.3-173.63)	2.583	0.010a
Heart rate (beats/min)		75.04 ± 9.836	74.87 ± 8.62	0.079	0.937
BMI		25.95 (24.54-27.66)	24.77 (24.00-27.28)	-1.487	0.137
Systolic pressure (mmHg)		129.18 ± 10.55	130.61 ± 10.70	-0.587	0.559
Diastolic pressure (mmHg)		83.94 ± 8.59	82.97 ± 6.44	0.540	0.591
Incidence of hypertension %		39 (79.6%)	30 (96.8%)	4.727	0.030a
SUA (umol/L)		474.41 ± 102.34	483.90 ± 107.97	-0.396	0.693
Scr (mmol/L)		92.78 ± 12.55	145.87 ± 48.14	-7.360	< 0.001c
BUN (mmol/L)		5.20 ± 1.06	9.35 ± 3.46	-7.857	< 0.001c
eGFR (ml/min/1.73 m2)		91.73 ± 14.82	40.91 ± 11.84	16.111	< 0.001c
Urine NAG (U/L)		0.70 (0.10-5.08)	0.70 (2.05-14.82)	3.402	0.001b
Urine RBP (mg/L)		0.20 (0.10-0.30)	0.58 (0.20-1.95)	3.059	0.002b
Urine β2-MG (mg/L)		0.20 (0.10-0.30)	0.30 (0.12-1.91)	2.615	0.009b
Urine Alb/Cr (mg/g)		4.79 (2.07-9.04)	45.76 (8.22-316.75)	4.504	< 0.001c

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

CKD: Chronic kidney disease; BMI: Body mass index; SUA: Serum uric acid; Scr: Serum creatinine; BUN: Blood urea nitrogen; eGFR: Estimated glomerular filtration rate; NAG: N-acetyl-beta-D-glucosidase; RBP: Retinol binding protein; β2-MG: β2-Microglobulin; Alb/Cr: Albumin-to-creatinine.