C-reactive protein as a non-linear predictor of prolonged length of intensive care unit stay after gastrointestinal cancer surgery

Table 2 Multivariable regression analysis for associations between C-reactive protein levels and prolonged intensive care unit length of stay

Exposure variable	Crude model		Multivariable-adjusted model 1		Multivariable-adjusted model 2
	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
CRP	2.12 (1.52, 2.98)	< 0.001	2.30 (1.56, 3.38)	< 0.001	1.47 (1.00, 2.17)	0.014
Tertiles
T1	1.0	--	1.0	--	1.0	--
T2	2.19 (0.84, 5.74)	0.109	2.29 (0.78, 6.72)	0.130	2.43 (0.62, 9.47)	0.200
T3	8.13 (3.36, 19.66)	< 0.001	10.03 (3.61, 27.83)	< 0.001	6.51 (1.74, 24.34)	0.005
Trend analysis	3.02 (1.96, 4.65)	< 0.001	3.42 (2.07, 5.63)	< 0.001	2.57 (1.35, 4.88)	0.004

Model 1: Adjusted for age, gender, laparoscopic surgery; Model 2: Adjusted for age, gender, laparoscopic surgery, emergency surgery, cancer site, intensive care unit readmission, tracheotomy, continuous renal replacement therapy, mechanical ventilation therapy, Acute Physiology and Chronic Health Evaluation II score. OR: Odds ratio; CI: Confidence interval; CRRT: Continuous renal replacement therapy; APACHE: Acute Physiology and Chronic Health Evaluation.