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©The Author(s) 2022.
World J Clin Cases. Nov 6, 2022; 10(31): 11358-11370
Published online Nov 6, 2022. doi: 10.12998/wjcc.v10.i31.11358
Published online Nov 6, 2022. doi: 10.12998/wjcc.v10.i31.11358
Table 2 Logistic regression analysis on the effect of predominant enterovirus serotypes in 168 laboratory-confirmed hand, foot, and mouth disease cases in Shiyan, central China, n (%)
HFMD pathogens | Univariate analysis | Multivariate analysis | |||||
CV-A6 (n = 121) | CV-A16 (n = 8) | CV-A10 (n = 5) | Other enteroviruses (n = 34) | P value | Coefficient (SD) | P value | |
Gender | 1 | -0.224 (0.451) | 0.619 | ||||
Male (n = 105) | 76 (62.8) | 5 (62.5) | 4 (80.0) | 20 (58.8) | |||
Female (n = 63) | 45 (37.2) | 3 (37.5) | 1 (20.0) | 14 (41.2) | |||
Age (yr) | 0.794 | ||||||
≤ 1 (n = 91) | 65 (53.7) | 4 (50.0) | 3 (60.0) | 19 (55.9) | |||
≤ 2 (n = 49) | 37 (30.6) | 2 (25.0) | 2 (40.0) | 8 (23.5) | 0.131 (0.497) | 0.792 | |
≤ 3 (n = 18) | 13 (10.7) | 0 (0.0) | 0 (0.0) | 5 (14.7) | 0.236 (0.717) | 0.742 | |
≤ 6 (n = 10) | 6 (5.0) | 2 (25.0) | 0 (0.0) | 2 (5.9) | -0.371 (0.785) | 0.637 | |
Fever | 0.013a | 2.124 (0.747) | 0.004b | ||||
Yes | 116 (95.9) | 5 (62.5) | 5 (100.0) | 29 (85.3) | |||
No | 5 (4.1) | 3 (37.5) | 0 (0.0) | 5 (14.7) | |||
Clinical manifestations | |||||||
Skin or oral mucosal rashes | 121 (100.0) | 8 (100.0) | 5 (100.0) | 34 (100.0) | |||
Respiratory system syndromes1 | 24 (19.8) | 3 (37.5) | 1 (20.0) | 3 (8.8) | 0.603 | 0.811 (0.589) | 0.168 |
Myocardial damage | 31 (25.6) | 1 (12.5) | 1 (20.0) | 2 (5.9) | 0.025a | 1.040 (0.678) | 0.125 |
Vomit | 0 (0.0) | 0 (0.0) | 1 (20.0) | 0 (0.0) | 0.623 | -15.923 (882.744) | 0.986 |
Laboratory findings, n (%, mean ± SD) | |||||||
WBC increased | 69 (56.6, 14.07 ± 3.42) | 4 (50.0, 19.82 ± 10.74) | 5 (100.0, 20.68 ± 7.67) | 15 (44.1, 13.88 ± 4.38) | 0.042a | -0.058 (0.050) | 0.247 |
CRP increased | 79 (64.8, 24.64 ± 26.90) | 5 (62.5, 25.28 ± 26.64) | 5 (100.0, 47.68 ± 29.52) | 15 (44.1, 25.97 ± 43.35) | 0.431 | -0.007 (0.006) | 0.271 |
CK-MB increased | 56 (45.9, 33.77 ± 13.78) | 2 (25.0, 30.00 ± 4.24) | 4 (80.0, 28.00 ± 6.48) | 17 (50.0, 30.94 ± 7.04) | 0.262 | 0.045 (0.027) | 0.097 |
LDH increased | 98 (80.3, 313.08 ± 59.37) | 6 (75.0, 298.17 ± 38.97) | 5 (100.0, 275.00 ± 24.81) | 27 (79.4, 334.52 ± 59.64) | 0.487 | -0.009 (0.004) | 0.043a |
ALT increased | 20 (16.4) | 1 (12.5) | 1 (20.0) | 3 (8.8) | 0.333 | -0.575 (1.328) | 0.665 |
AST increased | 29 (23.8) | 1 (12.5) | 1 (20.0) | 3 (8.8) | 0.086 | 1.778 (1.196) | 0.137 |
Radiographic evaluation | |||||||
Abnormal chest X-ray2 | 48 (39.3) | 4 (50.0) | 1 (20.0) | 8 (23.5) | 0.267 | 0.275 (0.449) | 0.540 |
Abnormal electrocardiogram3 | 24 (19.7) | 1 (12.5) | 1 (20.0) | 5 (14.7) | 0.389 | 0.236 (0.566) | 0.677 |
- Citation: Li JF, Zhang CJ, Li YW, Li C, Zhang SC, Wang SS, Jiang Y, Luo XB, Liao XJ, Wu SX, Lin L. Coxsackievirus A6 was the most common enterovirus serotype causing hand, foot, and mouth disease in Shiyan City, central China. World J Clin Cases 2022; 10(31): 11358-11370
- URL: https://www.wjgnet.com/2307-8960/full/v10/i31/11358.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v10.i31.11358