Longest survival with primary intracranial malignant melanoma: A case report and literature review

Figure 4 Immunohistochemical and histopathological analysis of confirmed recurrent melanoma at the 3^rd operation. A-D: Immunohistochemical staining of tumor cells showed positivity for (A) HMB-45, (B) S-100, (C) SOX-10, and (D) Ki67 (8%) (A1, B1, C1, and D1: × 200; A2, B2, C2, and D2: × 400); E: Hematoxylin-eosin staining showed that the tumor cells were diffusely distributed in flakes, with abundant cytoplasm, pigment granules in some cells, round or oval nuclei, nucleoli, and mitotic figures (3 cells/10 high power fields) (E1: × 100; E2: × 400).