Child with adenylosuccinate lyase deficiency caused by a novel complex heterozygous mutation in the ADSL gene: A case report

Figure 2 Structures of the wild-type and mutant adenylosuccinate lyase. A: The tertiary structure of wild-type mutant adenylosuccinate lyase (ADSL); B: The tertiary structure of mutant ADSL; C: The secondary structure of wild-type ADSL; D: The predicted results of amino acid polarity in wild-type ADSL; E: The secondary structure of p. Pro24Leu ADSL; F: The predicted results of amino acid polarity in p. Pro24Leu ADSL. The green regions in panels A and B indicate substantial changes in protein structure.