Clinical characteristics and prognosis of non-small cell lung cancer patients with liver metastasis: A population-based study

Table 2 Univariate and multivariate analyses of cancer-specific survival in the training cohort

Characteristic	Univariate analysis			Multivariate analysis
	HR	95%CI of HR	P value	HR	95%CI of HR	P value
Age, yr
≥ 65 vs < 65	1.312	1.221-1.411	< 0.001	1.236	1.147-1.332	< 0.001
Marital status
Unmarried vs Married	1.245	1.158-1.338	< 0.001	1.103	1.023-1.189	0.011
Sex
Male vs Female	1.219	1.134-1.311	< 0.001	1.196	1.109-1.289	< 0.001
Race
White vs Black	1.128	1.043-1.221	0.003	1.061	0.953-1.182	0.281
Other1 vs Black	0.781	0.714-0.855	< 0.001	0.718	0.610-0.844	< 0.001
Pathological type
ADC vs SCC	0.814	0.749-0.884	< 0.001	0.905	0.829-0.988	0.026
Other NSCLCs vs SCC	0.786	0.677-0.913	0.002	0.880	0.756-1.025	0.101
T stage
T2 vs T1	1.195	1.052-1.357	0.006	1.179	1.037-1.340	0.012
T3 vs T1	1.277	1.124-1.451	< 0.001	1.226	1.078-1.395	0.002
T4 vs T1	1.358	1.201-1.536	< 0.001	1.308	1.155-1.482	< 0.001
N stage
N1 vs N0	1.050	0.901-1.225	0.530	-	-	-
N2 vs N0	1.019	0.925-1.122	0.709	-	-	-
N3 vs N0	0.988	0.883-1.105	0.831	-	-	-
Metastatic pattern
Liver + bone vs Liver only	1.181	1.086-1.285	< 0.001	1.281	1.176-1.396	< 0.001
Liver + brain vs Liver only	1.328	1.166-1.512	< 0.001	1.541	1.351-1.758	< 0.001
Liver + bone+ brain vs liver only	1.244	1.121-1.381	< 0.001	1.562	1.400-1.742	< 0.001
Radiotherapy
Yes vs No/unknown	0.967	0.900-1.040	0.364	-	-	-
Chemotherapy
Yes vs No/unknown	0.346	0.321-0.373	< 0.001	0.352	0.326-0.381	< 0.001

¹Other only includes American Indian/Alaskan Native and Asian/Pacific Islander.

HR: Hazard ratio; CI: Confidence interval; ADC: Adenocarcinoma; SCC: Squamous cell carcinoma; NSCLC: Non-small cell lung cancer.