Clinical characteristics and prognosis of non-small cell lung cancer patients with liver metastasis: A population-based study

doi:10.12998/wjcc.v10.i30.10882

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Oct 26, 2022 (publication date) through Jul 23, 2024

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World Journal of Clinical Cases

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Retrospective Cohort Study

World J Clin Cases. Oct 26, 2022; 10(30): 10882-10895
Published online Oct 26, 2022. doi: 10.12998/wjcc.v10.i30.10882

Table 1 Baseline characteristics of the overall, training, and validation cohorts

Characteristic	Overall cohort (n = 4475)	Training cohort (n = 3135)	Validation cohort (n = 1340)	P value
Age, yr				0.839
Median (range)	67 (23-96)	67 (23-96)	66 (32-93)
< 65	1930 (43.1)	1349 (43.0)	581 (43.4)
≥ 65	2545 (56.9)	1786 (57.0)	759 (56.6)
Marital status				0.413
Married	2463 (55.0)	1713 (54.6)	750 (56.0)
Unmarried	2012 (45.0)	1422 (45.4)	590 (44.0)
Sex				0.808
Female	1938 (43.3)	1354 (43.2)	584 (43.6)
Male	2537 (56.7)	1781 (56.8)	756 (56.4)
Race				0.263
Black	566 (12.6)	413 (13.2)	153 (11.4)
White	3517 (78.6)	2451 (78.2)	1066 (79.6)
Other¹	392 (8.8)	271 (8.6)	121 (9.0)
Primary site				0.922
UL	2452 (54.8)	1725 (55.0)	727 (54.3)
ML	198 (4.4)	133 (4.2)	65 (4.9)
LL	1219 (27.2)	853 (27.2)	366 (27.3)
MB	240 (5.4)	167 (5.3)	73 (5.4)
Other	366 (8.2)	257 (8.2)	109 (8.1)
Histological type				0.786
ADC	2967 (66.3)	2085 (66.5)	882 (65.8)
SCC	1169 (26.1)	810 (25.8)	359 (26.8)
Other NSCLCs	339 (7.6)	240 (7.7)	99 (7.4)
T stage				0.910
T1	507 (11.3)	362 (11.5)	145 (10.8)
T2	1197 (26.7)	839 (26.8)	358 (26.7)
T3	1204 (26.9)	839 (26.8)	365 (27.2)
T4	1567 (35.0)	1095 (34.9)	472 (35.2)
N stage				0.170
N0	831 (18.6)	596 (19.0)	235 (17.5)
N1	358 (8.0)	239 (7.6)	119 (8.9)
N2	2312 (51.7)	1601 (51.1)	711 (53.1)
N3	974 (21.8)	699 (22.3)	275 (20.5)
Metastatic pattern				0.166
Liver only	1598 (35.7)	1117 (35.6)	481 (35.9)
Liver + bone	1701 (38.0)	1166 (37.2)	535 (39.9)
Liver + brain	415 (9.3)	301 (9.6)	114 (8.5)
Liver + bone + brain	761 (17.0)	551 (17.6)	210 (15.7)
Radiotherapy				0.497
Yes	1871 (41.8)	1321 (42.1)	550 (41.0)
No/unknown	2604 (58.2)	1814 (57.9)	790 (59.0)
Chemotherapy				0.287
Yes	2417 (54.0)	1677 (53.5)	740 (55.2)
No/unknown	2058 (46.0)	1458 (46.5)	600 (44.8)

¹Other only includes American Indian/Alaskan Native and Asian/Pacific Islander.

UL: Upper lobe; ML: Middle lobe; LL: Lower lobe; MB: Main bronchus; ADC: Adenocarcinoma; SCC: Squamous cell carcinoma; NSCLC: Non-small cell lung cancer.

Citation: Wang JF, Lu HD, Wang Y, Zhang R, Li X, Wang S. Clinical characteristics and prognosis of non-small cell lung cancer patients with liver metastasis: A population-based study. World J Clin Cases 2022; 10(30): 10882-10895
URL: https://www.wjgnet.com/2307-8960/full/v10/i30/10882.htm
DOI: https://dx.doi.org/10.12998/wjcc.v10.i30.10882