Atrial fibrillation burden and the risk of stroke: A systematic review and dose-response meta-analysis

Figure 3 Trial sequential analysis of atrial fibrillation burden > 5 min. Heterogeneity adjusted required information size of 51978 participants calculated on basis of incidence of 2.37% in control group, relative risk reduction of 30%, α = 5%, β = 20%, and I² = 30%. Actually, accrued number of participants was 37144, 71.5% of required information size. AF: Atrial fibrillation.