Evaluating tumor-infiltrating lymphocytes in hepatocellular carcinoma using hematoxylin and eosin-stained tumor sections

Figure 1 The distribution and recurrence association of tumor infiltrating lymphocytes in the tumor center, invasive front, and peritumor. A: The spectrum of tumor infiltrating lymphocytes in the tumor center (TILs^CT), TILs in the invasive front (TILs^IF), and TILs in the peritumor (PILs) of 204 cases. TILs^CT were lower than TILs^IF and PILs. TILs^IF was the most flaming part than the other two areas; B: Dot map of TILs^CT, TILs^IF, and PILs, indicating a heterogeneous distribution of inflammation; C: Comparison of the mean of TILs^CT, TILs^IF and PILs from patients with tumor recurrence (black bars) or without tumor recurrence (white bars); D: Median survival time for all patients, with high densities (red bars) or low densities (black bars) of TILs^CT, TILs^IF and PILs; E, F and G: Patients with high TILs^CT, TILs^IF, and PILs had a lower recurrence rate. TILs^CT: Tumor infiltrating lymphocytes in the tumor center; TILs^IF: Tumor infiltrating lymphocytes in the invasive front 1 mm spacing from the malignant nests; PILs: infiltrating lymphocytes in the peritumor.