Dynamic monitoring of carcinoembryonic antigen, CA19-9 and inflammation-based indices in patients with advanced colorectal cancer undergoing chemotherapy

Table 4 Area under the curve and cut-off values

Test result variable (s)	Area	Asymptotic Sig.	Asymptotic 95% CI
			Lower bound	Upper bound	Cut- off value for PD, %	Sensitivity	Specificity	Cut -off value for sensitivity 1, %	Specificity for sensitivity 1	Avoidable CT, %
∆CEA	0.842g	0.000	0.788	0.895	24.52	0.803	0.804	-60.85	0.357	52 (25.49)
∆CA19-9	0.769f	0.000	0.665	0.874	21.49	0.67	0.76	-55.38	0.396	22 (16.92)
∆NeLR	0.713f	0.000	0.614	0.182	11.05	0.67	0.66	-77.85	0.013	2 (3.4%)
∆LMR	0.451fl	P > 0.05	0.309	0.562
∆PLR	0.622p	0.036	0.511	0.733	5.9	0.53	0.68	-59.33	0.075	6 (10.3)
∆SII	0.723f	0.000	0.625	0.82	-6.04	0.72	0.63	-88.62	0.013	2 (3.4)

^eP ≥ 0.9-1 excellent.

^gP ≥ 0.8-0.9 good.

^fP ≥ 0.7-0.8 fair/acceptable.

^pP ≥ 0.6-0.7 poor.

^flP ≥ 0.5-0.6 failed, that’s a qualitative interpretation of the area under the curve (AUC). The area under the receiver operating characteristic curve (AUC) results were considered excellent for AUC values between 0.9 and 1, good for AUC values between 0.8 and 0.9, fair for AUC values between 0.7 and 0.8, poor for AUC values between 0.6 and 0.7 and failed for AUC values between 0.5 and 0.6. CEA: Carcinoembryonic antigen.