Evaluating tumor-infiltrating lymphocytes in hepatocellular carcinoma using hematoxylin and eosin-stained tumor sections

Table 3 Clinicopathological data between the three immune subtypes

Variable		Immunehigh	Immunemod	Immunelow
HBV DNA	Positive	30	30	5
	Negative	38	54	16
	Not mentioned	15	10	6
MaVI	Yes	8	10	3
	No	75	84	24
MVI	Yes	34	58	18
	No	49	36	9
Tumor number	Single	60	78	18
	Multiple (≥ 2)	23	16	9
Largest tumor diameter	≤ 10	80	85	24
	> 10	3	9	3
Capsule	Yes	48	53	16
	No	35	41	11
Neutrophils	Yes	19	19	1
	No	64	75	26
Tertiary lymphoid structures	Yes	7	3	0
	No	76	91	27
Differentiation	Moderately differentiated	40	50	17
	Poorly differentiated	43	44	10
Histological subtype	Microtrabecular/pseudoglandular	39	40	13
	Macrotrabecular	38	52	14
	Compact	3	2	0
	Lymphoepithelioma-like	3	0	0
PD-L1 expression	Tumor cells	24	44	12
	TILs	79	94	26
Recurrence	Yes	9	24	9
	No	74	70	18

MaVI: Macrovascular invasion; MVI: Microvascular invasion; PD-L1: Programmed cell death-ligand 1; TIL: Tumor infiltrating lymphocyte; HBV: Hepatitis B virus.