Evaluating tumor-infiltrating lymphocytes in hepatocellular carcinoma using hematoxylin and eosin-stained tumor sections

Table 2 Results of univariate and multivariate analysis

Variable	Univariate analysis			Multivariate analysis
	HR	95% CI	P value	HR	95% CI	P value
MaVI	3.09	1.02-9.34	0.001	3.77	1.63-7.40	0.009
MVI	2.80	1.51-5.16	0.012	1.19	0.64-2.23	0.693
Tumor number	2.38	1.10-5.14	0.008	1.95	1.04-3.77	0.122
Largest tumor diameter	3.31	1.06-10.32	0.001	1.76	0.95-3.45	0.322
Capsule	1.99	1.07-3.70	0.026	0.42	0.20-0.83	0.031
Macrotrabecular histological subtype	3.22	1.77-5.86	0.001	1.89	1.03-3.67	0.104
TILsCT (≤ 30)	0.49	0.22-0.92	0.039	0.85	0.41-1.63	0.734
TILsIF (≤ 200)	0.37	0.14-0.98	0.014	0.46	0.25-0.86	0.047
PILs (≤ 200)	0.40	0.22-0.75	0.010	0.37	0.19-0.77	0.0495

MaVI: Macrovascular invasion; MVI: Microvascular invasion; TILs^CT: Tumor infiltrating lymphocytes in the tumor center; TILs^IF: Tumor infiltrating lymphocytes in the invasive front 1 mm spacing from the malignant nests; PILs: Infiltrating lymphocytes in the peritumor; HR: Hazard ratio; CI: Confidence interval.