Cutaneous allergic reaction to subcutaneous vitamin K1: A case report and review of literature

Figure 1 Clinical presentation and diagnostic clues from the original symptoms. A and B: Intensely pruritic, weeping, erythematous, eczematous, and indurated plaques; C: An intense perivascular infiltrate composed of lymphocytes and histiocytic cells, with rare plasma cells and eosinophils (hematoxylin–eosin stain, 100 ×); D: Prominent endothelial cell swelling. The infiltrate extended through the reticular dermis into the subcutaneous fat and focally surrounded the eccrine and neural structures (hematoxylin–eosin stain, 400 ×); E and F: The lower half of the dermis was markedly sclerotic with thickened eosinophilic collagen bundles. A microscopic examination revealed a normal epidermis and more lymphocytes infiltrating the blood vessels in the dermis, several of which were mimicking Pautrier microabscesses (100 ×).