Development and validation of a prognostic nomogram for decompensated liver cirrhosis

Table 3 The validation of the nomogram versus two scores by net reclassification index and integrated discrimination improvement index

Index	Derivation cohort			Validation cohort
	Estimate	95%CI	P value	Estimate	95%CI	P value
NRI versus CTP
For 28-d mortality	0.419	0.192-0.606	< 0.001a	0.395	0.061-0.662	0.020a
For 3-mo mortality	0.355	0.134-0.488	0.007a	0.241	0.005-0.490	0.040a
For 6-mo mortality	0.319	0.081-0.481	< 0.001a	0.227	0.120-0.480	< 0.001a
NRI vs MELD
For 28-d mortality	0.395	0.214-0.548	< 0.001a	0.578	0.364-0.740	< 0.001a
For 3-mo mortality	0.305	0.080-0.417	0.013a	0.388	0.233-0.547	< 0.001a
For 6-mo mortality	0.281	0.077-0.402	0.007a	0.358	0.249-0.527	< 0.001a
IDI vs CTP
For 28-d mortality	0.262	0.181-0.394	< 0.001a	0.253	0.095-0.426	< 0.001a
For 3-mo mortality	0.193	0.118-0.285	< 0.001a	0.167	0.040-0.308	0.020a
For 6-mo mortality	0.178	0.098-0.270	< 0.001a	0.152	0.013-0.294	< 0.001a
IDI vs MELD
For 28-d mortality	0.133	0.070-0.247	< 0.001a	0.322	0.195-0.473	< 0.001a
For 3-mo mortality	0.081	0.026-0.151	< 0.001a	0.220	0.122-0.343	< 0.001a
For 6-mo mortality	0.064	0.023-0.133	< 0.001a	0.212	0.132-0.298	< 0.001a

^aSignificant P value.

NRI: Net reclassification index; CTP: Child-Turcotte-Pugh; MELD: Model for end-stage liver disease; IDI: Integrated discrimination improvement index.