Clinicopathological characteristics and prognosis of gastric signet ring cell carcinoma

Table 4 Analysis of survival and prognosis of patients with advanced gastric cancer

Variable	OS (AGC = 3895), or (95%CI)	P value	OS (SRC = 1013), or (95%CI)	P value
Age (yr)		< 0.001		< 0.001
< 40	1 (Reference)		1 (Reference)
40-60	1.130 (0.882-1.447)	0.333	1.267 (0.898-1.788)	0.178
60-80	1.543 (1.212-1.985)	< 0.001	1.578 (1.123-2.218)	0.009
> 80	2.936 (2.281-3.780)	< 0.001	2.290 (1.528-3.431)	< 0.001
Race		< 0.001		< 0.001
White	1 (Reference)		1 (Reference)
Black	1.096 (0.973-1.234)	0.133	1.326 (1.057-1.663)	0.015
Black-AI	1.382 (0.949-2.015)	0.092	2.624 (1.423-4.838)	0.002
Black-API	0.726 (0.651-0.810)	< 0.001	0.800 (0.867-1.205)	0.041
Sex
Male	1 (Reference)		1(Reference)
Female	0.964 (0.883-1.052)	0.409	1.022 (0.867-1.205)	0.791
Tumor size (cm)		< 0.001		0.001
< 2	1 (Reference)		1 (Reference)
2-5	1.026 (0.823-1.280)	0.817	1.031 (0.680-1.565)	0.885
> 5	1.211 (0.971-1.511)	0.089	1.415 (0.930-2.152)	0.105
AJCC stage		0.019		0.028
I	1 (Reference)		1 (Reference)
II	1.227 (0.903-1.667)	0.191	1.946 (0.923-4.102)	0.080
III	1.584 (1.076-2.330)	0.020	3.050 (1.247-7.458)	0.015
T stage		< 0.001		< 0.001
T2	1 (Reference)		1 (Reference)
T3	1.384 (1.135-1.689)	0.001	1.857 (1.189-2.899)	0.006
T4	2.025 (1.633-2.512)	< 0.001	2.615 (1.644-4.161)	< 0.001
N stage		< 0.001		0.086
N0	1 (Reference)		1 (Reference)
N1	1.241 (1.056-1.459)	0.009	1.061 (0.744-1.512)	0.745
N2	1.295 (1.050-1.597)	0.016	1.034 (0.665-1.608)	0.881
N3	1.904 (1.549-2.341)	< 0.001	1.341 (0.882-2.037)	0.170
Histology		0.002
Differentiated	1 (Reference)
SRC	1.276 (1.117-1.458)	< 0.001
Undifferentiated	1.164 (1.037-1.306)	0.010
SRC vs non-SRC	1.139 (1.030-1.258)	0.011
Adjuvant therapy				< 0.001
Radiotherapy			0.635 (0.367-1.099)	0.105
Chemotherapy			0.481 (0.388-0.595)	< 0.001
Radiotherapy + Chemotherapy			0.414 (0.334-0.512)	< 0.001
None			1 (Reference)

OS: Overall survival; SRC: Signet ring cell carcinoma; AGC: Advanced gastric cancer; API: Asian Pacific Islanders; AI: American Indians.