Clinicopathological characteristics and prognosis of gastric signet ring cell carcinoma

Table 3 Analysis of survival and prognosis of patients with early gastric cancer

Variable	OS (EGC = 1305) or (95%CI)	P value	OS (SRC = 313) or (95%CI)	P value
Age (yr)		< 0.001		0.128
< 40	1 (Reference)		1 (Reference)
40-60	1.189 (0.282-5.015)	0.813	1.071 (0.128-8.947)	0.950
60-80	2.246 (0.550-9.174)	0.260	2.072 (0.268-16.012)	0.485
> 80	5.516 (1.337-22.753)	0.018	4.204 (0.463-38.177)	0.202
Race		< 0.001		0.093
White	1 (Reference)		1 (Reference)
Black	1.459 (1.053-2.022)	0.023	2.052 (0.878-4.793)	0.097
Black-AI	1.947 (0.476-7.960)	0.354	0.000	0.990
Black-API	0.497 (0.358-0.691)	< 0.001	0.471 (0.137-1.271)	0.124
Sex
Male	1 (Reference)		1 (Reference)
Female	0.610 (0.467-0.797)	< 0.001	0.791 (0.383-1.632)	0.526
Tumor size (cm)		0.057		0.700
< 2	1 (Reference)		1 (Reference)
2-5	1.317 (0.982-1.764)	0.066	1.579 (0.707-3.525)	0.265
> 5	1.859 (1.161-2.978)	0.010	0.000	0.974
AJCC stage
I	1 (Reference)		1 (Reference)
II	1.836 (1.100-3.064)	0.020	0.965 (0.231-4.027)	0.961
Depth
T1a	1 (Reference)		1 (Reference)
T1b	1.280 (0.962-1.703)	0.090	1.786 (0.810-3.938)	0.151
LNM1
N0	1 (Reference)		1 (Reference)
N1-3	1.271 (0.859-1.880)	0.230	2.134 (0.883-5.154)	0.151
Histology		0.045
Differentiated	1(Reference)
SRC	0.636 (0.426-0.950)	0.027
Undifferentiated	1.039 (0.780-1.384)	0.794
SRC vs non-SRC	0.626 (0.427-0.919)	0.017

¹LNM: Lymph node metastasis.

OS: Overall survival; SRC: Signet ring cell carcinoma; EGC: Early gastric cancer; API: Asian Pacific Islanders; AI: American Indians.