Clinicopathological characteristics and prognosis of gastric signet ring cell carcinoma

Table 2 Comparison of general characteristics of patients with different differentiated types of gastric cancer

Variable	Differentiated (%), n = 1550	P value	SRC (%), n = 1326	P value	Undifferentiated (%), n = 2324
Age (yr)
< 40	13 (0.84)	< 0.001	110 (8.30)	< 0.001	77 (3.31)
40-60	241 (15.55)	< 0.001	518 (39.06)	< 0.001	630 (27.11)
60-80	920 (59.35)	< 0.001	583 (43.97)	< 0.001	1187 (51.08)
> 80	376 (24.26)	< 0.001	115 (8.67)	< 0.001	430 (18.50)
Sex		< 0.001		< 0.001
Male	959 (61.87)		625 (47.13)		1349 (58.05)
Female	591 (38.13)		701 (52.87)		975 (41.95)
Race
White	804 (51.87)	< 0.001	819 (61.74)	0.005	1324 (56.97)
Black	295 (19.03)	0.001	188 (14.19)	0.536	347 (14.93)
Black-AI	16 (1.03)	0.890	13 (0.98)	0.978	23 (0.99)
Black-API	435 (28.07)	0.002	306 (23.09)	0.007	630 (27.11)
T stage
T1a	281 (18.13)	0.004	187 (14.10)	< 0.001	129 (5.56)
T1b	325 (20.97)	< 0.001	126 (9.51)	0.140	257 (11.06)
T2	242 (15.61)	0.002	155 (11.69)	0.355	296 (12.74)
T3	450 (29.03)	0.930	383 (28.89)	< 0.001	864 (37.17)
T4a	171 (11.03)	< 0.001	385 (29.03)	0.033	599 (25.77)
T4b	81 (5.23)	0.078	90 (6.78)	0.309	179 (7.70)
N stage
N0	946 (61.03)	< 0.001	512 (38.61)	0.001	775 (33.35)
N1	278 (17.94)	0.097	207 (15.61)	0.001	466 (20.05)
N2	181 (11.68)	0.010	198 (14.93)	< 0.001	476 (20.48)
N3	145 (9.35)	< 0.001	409 (30.85)	0.002	607 (26.12)
AJCC stage
I	730 (47.10)	< 0.001	372 (28.05)	< 0.001	478 (20.57)
II	452 (29.16)	< 0.001	305 (23.00)	< 0.001	692 (29.78)
III	368 (23.74)	< 0.001	649 (48.95)	0.679	1154 (49.65)
Primary site
Fundus	67 (4.32)	0.084	41 (3.09)	0.665	78 (3.36)
Body	198 (12.77)	0.527	180 (13.58)	0.898	319 (13.73)
Antrum	640 (41.29)	< 0.001	434 (32.73)	0.061	832 (35.80)
Pylorus	85 (5.48)	0.879	71 (5.36)	0.687	132 (5.68)
Lesser curve	228 (14.71)	0.694	202 (15.23)	0.452	376 (16.18)
Lesser curve-Greater curve	85 (5.48)	0.294	85 (6.41)	0.218	126 (5.42)
Lesser curve-Overlapping/NOS	247 (15.95)	< 0.001	313 (23.60)	0.007	461 (19.83)
Radiotherapy		< 0.001		0.410
Yes	304 (19.61)		415 (31.30)		697 (29.99)
No	1246 (80.39)		911 (68.70)		1627 (70.01)
Chemotherapy		< 0.001		0.015
Yes	535 (34.52)		785 (59.20)		1279 (55.03)
No	1015 (65.48)		541 (40.80)		1045 (44.97)
Tumor size (cm)
< 2	354 (22.84)	< 0.001	212 (15.99)	< 0.001	254 (10.93)
2-5	674 (43.48)	0.008	512 (38.61)	0.004	1012 (43.55)
> 5	420 (27.10)	0.017	413 (31.15)	< 0.001	867 (37.31)
NA	102 (6.58)	< 0.001	189 (14.25)	< 0.001	191 (8.21)

SRC: Signet ring cell carcinoma; API: Asian Pacific Islanders; AI: American Indians.