Age-adjusted NT-proBNP could help in the early identification and follow-up of children at risk for severe multisystem inflammatory syndrome associated with COVID-19 (MIS-C)

Table 5 Dynamics of cardiac parameters during the follow-up in this study. Comparison between groups regarding duration of respiratory support

Cardiac parameter	Admission	24 h after AIT	Discharge	After 1-mo fu.
NT-proBNP (Z-log value adjusted for age)2	4.62 (4.46-5.23)	3.78 (3.26-4.87)1	1.79 (0.66-2.5)1	0.72 (0.21-1.29)1
Log (10)-Hs-TnI (ng/L)2	35 (10-116)	13 (5-35)1	10 (10-13)1	10 (10-10)
LVEF (%)2	58 (48-65)	68 (65-70)1	70 (66-72)	70 (68-71)
Coronary arteries maximal dimension (Z-score for BSA)2	1.39 (0.56-2.66)	1.2 (0.77-1.5)	1 (0.5-1.2)1	0.8 (0.51-1.2)
Age-based Ross classification for heart failure in children2	8 (4-12)	3 (2-7)1	0 (0-0)1	0 (0-0)

¹P value < 0.05 for Wilcoxon sign rank test comparing the indicated value with the value in the previous time (its left column).

²Data presented in median and interquartile range.

NT-proBNP: N-Terminal pro-brain natriuretic peptide; Hs-TnI: High sensitivity-troponin I; LVEF: Left ventricle ejection fraction; BSA: Body surface area.