Age-adjusted NT-proBNP could help in the early identification and follow-up of children at risk for severe multisystem inflammatory syndrome associated with COVID-19 (MIS-C)

doi:10.12998/wjcc.v10.i29.10435

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Oct 16, 2022; 10(29): 10435-10450
Published online Oct 16, 2022. doi: 10.12998/wjcc.v10.i29.10435

Table 4 Treatment and clinical outcomes of the study population

N = 17	Results
IVIG¹	14 (82)
Steroids¹	16 (94)
Aspirin¹	15 (88)
LWH¹	3 (17)
Anakinra¹	3 (17)
Tocilizumab¹	1 (6)
Antibiotics¹	15 (88)
Diuretics¹	10 (53)
Beta blockers¹	6 (35)
ACEIs¹	6 (35)
Antiarrhythmics¹	0 (0)
Oxygen (nasal cannula)¹	2 (11)
CPAP¹	1 (6)
Mechanical ventilation¹	1 (6)
Inotropics¹	7 (41)
ECMO¹	0 (0)
Resistance to immunomodulatory therapy¹	4 (23)
PICU admission¹	7 (41)
PICU stay (days)²	3.5 (3-4.5)
LOS hospitalization (days)²	7 (5-10)
Heart failure at discharge¹	1 (6)
Myocardial dysfunction at discharge¹	1 (6)
Coronary artery dilation at discharge¹	2 (11)
Raised hs-TnI or NT-proBNP at discharge¹	9 (53)
Cardiac medications at discharge¹	8 (47)
Any cardiac sequelae or medications at 1 month follow-up¹	0 (0)
Death¹	0 (0)

¹Data presented in frequency and percentage.

²Data presented in median and interquartile range.

IVIG: Intravenous immunoglobulin; LWH: Low molecular weight heparin; ACEis: Angiotensin-converting enzyme inhibitors; CPAP: Continuous positive airway pressure; ECMO: Extracorporeal membrane oxygenation; PICU: Pediatric intensive care unit; LOS: Length of stay; Hs-TnI: High sensitivity-troponin I; NT-proBNP: N-Terminal pro brain natriuretic peptide.

Citation: Rodriguez-Gonzalez M, Castellano-Martinez A. Age-adjusted NT-proBNP could help in the early identification and follow-up of children at risk for severe multisystem inflammatory syndrome associated with COVID-19 (MIS-C). World J Clin Cases 2022; 10(29): 10435-10450
URL: https://www.wjgnet.com/2307-8960/full/v10/i29/10435.htm
DOI: https://dx.doi.org/10.12998/wjcc.v10.i29.10435