Age-adjusted NT-proBNP could help in the early identification and follow-up of children at risk for severe multisystem inflammatory syndrome associated with COVID-19 (MIS-C)

Table 3 Baseline laboratory and echocardiographic data of the study population

N = 17	Results
Leukocytes (/µL)2	9930 (83490-12250)
Leukocytosis1	4 (23)
Lymphocytes (/µL)2	1480 (680-3100)
Lymphopenia1	9 (53)
Hemoglobin (g/dL)2	10.7 (8-12.2)
Anemia1	8 (47)
Thrombocytes (/µL)2	161000 (120000-238000)
Thrombocytopenia1	5 (29)
Dimer D (ng/mL)2	3504 (3284-5290)
Coagulopathy1	7 (41)
CRP (mg/L)2	171 (121-201)
Procalcitonin (ng/mL)2	3.2 (1.4-10.2)
Ferritin (ng/mL)2	789 (552-978)
Creatinine (mg/dL)2	0.5 (0.4-0.57)
Urea (mg/dL)2	23 (19-31)
AKI1	2 (11)
Sodium (mEq/L)2	134 (131-137)
Hyponatremia1	8 (47)
GPT (U/L)2	40 (25-66)
Hypertransaminemia1	6 (35)
pH2	7.37 (7.34-7.4)
pCO2 (mmHg)2	37 (33-39)
HCO3 (mmol/L)2	23 (21-24)
Acidosis1	4 (23)
NT-proBNP (pg/mL)2	5221 (2638-10020)
NT-proBNP (Z-log value adjusted for age)2	4.62 (4.46-5.23)
High NT-proBNP (Z-log for age > 2)1	17 (100)
Very high NT-proBNP (Z-log for age > 4)1	12 (71)
hs-TnI (ng/L)2	35 (10-116)
High hs-TnI (> 50 ng/L)1	5 (29)
LVEF (%)2
LV dysfunction, n (%)1
Maximal CA diameter (Z-score)2
CA dilation1

¹Data presented in frequency and percentage.

²Data presented in median and interquartile range.

CRP: C reactive protein; AKI: Acute kidney injury; NT-proBNP: N-Terminal Pro-Brain Natriuretic Peptide; Hs-TnI: High Sensitivity-Troponin I; LVEF: Left ventricle ejection fraction; LF: Left Ventricle; CA: Coronary artery.