One-stage resection of four genotypes of bilateral multiple primary lung adenocarcinoma: A case report

Table 1 Gene sequencing of four primary lung adenocarcinoma lesions

Nodule location	Mutant gene	Detection result	Abundance/NDF, %
Upper lobe of left lung	EGFR	Exon 21 c.2573T>G p.L858R	4.05
Lower lobe of left lung	ERBB2	Exon 20 c.2310_2311i nsGCATAC GTGATG p.E770_A77 1insAYVM	25.40
	TP53	exon 8 c.796G>A p.G266R	2.84
Upper lobe of right lung	EGFR	Exon 19 c.2238_2252 delATTAAG AGAAGCA AC p.L747_T751 del	10.24
Lower lobe of right lung	EGFR	Exon 18 c.2156G>C p.G719A	8.89

EGFR: Epidermal growth factor receptor; ERBB2: Erb-B2 receptor tyrosine kinase 2; TP53: Tumor protein p53. NDF is the logarithmic value of the ratio of the number of fusion-supported reads at the site to the total number of reads in the sample (log value). NDF < 0, the larger the NDF value, the more the number of supported fusion reads is detected.