Clinical Trials Study
Copyright ©The Author(s) 2022.
World J Clin Cases. Oct 6, 2022; 10(28): 10085-10096
Published online Oct 6, 2022. doi: 10.12998/wjcc.v10.i28.10085
Table 3 Characteristics of seven patients developing genotypic mutations to entecavir

Group A (entecavir)
Group B (entecavir maleate)
Patient 1
Patient 2
Patient 3
Patient 4
Patient 5
Patient 6
Patient 7
Age, yr32342829433421
SexMaleMaleMaleMaleMaleMaleMale
Prior LAM exposureYesYesNoNoYesYesNo
Prior ADV exposureYesYesNoNoYesNoNo
Baseline
HBeAg statusPositive PositivePositivePositivePositivePositivePositive
HBV DNA, log10 IU/mL6.697.998.065.327.777.477.81
LAM resistanceNoNoNoNoNoYesNo
ADV resistanceYesYesNoNoYesNoNo
At maximum viral suppression
wk244872844812120
HBV DNA, log10 IU/mL4.071.182.971.762.264.78TND
At time of resistance confirmed
wk144144144144144144144
HBV DNA, log10 IU/mL6.916.044.411.736.734.961.79
Mutational patternrtL180MrtL180MrtL180MrtL180MrtL180MrtL180MrtL180M
rtS202GrtS202GrtS202GrtV173LrtT184SrtS202GrtT184S
rtM204VrtM204VrtM204VrtM204VrtM204VrtM204VrtM204V
rtM250V
Addition of ADVYesYesYesNoYesYesNo
HBV DNA, log10 IU/mL
Week 1685.145.083.181.843.434.86TND
Week 1924.22.773.1Missing2.894.28Missing