Review of the pharmacological effects of astragaloside IV and its autophagic mechanism in association with inflammation

Table 5 Protective effect of astragaloside IV on organ injury

Disease categories	Study object/model	Effect induced by autophagy	Mechanism (targets or pathways)	Ref.
Liver injury	Iron overload (iron dextran) in LO2 cells	(-) Damage to hepatocytes, excessive autophagy, autophagosomes and apoptosis of hepatocytes by the iron overload	(-) LC3 II/I, (+) p62	Xie et al[43]
Liver and kidney injury	Cisplatin in rats	Protected against cisplatin-induced injury by (+) autophagy	(-) Autophagy-mediated NLRP3	Qu et al[44]

LO2: Human normal embryonic hepatocytes; LC: Lung cancer; NLRP3: NLR family, pyrin domain containing 3.