Meta-Analysis
Copyright ©The Author(s) 2022.
World J Clin Cases. Sep 26, 2022; 10(27): 9703-9713
Published online Sep 26, 2022. doi: 10.12998/wjcc.v10.i27.9703
Table 2 Grade 3/4 toxicity with gemcitabine plus nab-paclitaxel + a targeted drug and gemcitabine plus nab-paclitaxel + placebo in metastatic pancreatic cancer
Grade 3/4 toxicity
GA+ a targeted drug (n/N)
GA+ placebo (n/N)
Analysis model
OR (95%CI)
Z
P
Fatigue367/777264/607Fixed effect1.07 (0.88,1.29)0.6420.522
Anemia166/452169/451Fixed effect0.97 (0.75,1.25)0.2250.822
Vomiting221/663160/497Fixed effect1.07 (0.84,1.36)0.5320.595
Neutropenia150/452158/451Fixed effect0.94 (0.73,1.22)0.4440.657
Diarrhea281/452194/451Fixed effect1.46 (1.17,1.83)3.309< 0.01