Prognostic significance of sex determining region Y-box 2, E-cadherin, and vimentin in esophageal squamous cell carcinoma

Table 3 Univariate and multivariate analyses of factors associated with overall survival

Characteristic	Univariate analysis			Multivariate analysis
	Hazard ratio	95%CI	P value	Hazard ratio	95%CI	P value
Age, yr (≥ 65 vs < 65)	1.23	0.88-1.71	0.233
Gender (Female vs Male)	0.94	0.66-1.36	0.753
Ethnicity (Han vs Kazakh)	1.05	0.75-1.46	0.782
Tumor size (≥ 3 cm vs < 3 cm)	0.92	0.64-1.33	0.658
Tumor location (Upper vs Middle and Lower)	1.08	0.80-1.47	0.605
AJCC stage (I vs II vs III vs IV)	1.21	0.96-1.51	0.100
Lymph node metastasis (No vs Yes)	1.41	0.99-2.00	0.058
Metastasis (No vs Yes)	1.70	0.83-3.48	0.147
Degree of differentiation (High vs Moderate vs Poor)	0.76	0.56-1.02	0.069
E-cadherin expression (Positive vs Negative)	1.18	0.84-1.66	0.337
Invasion (Mucosa vs Muscularis vs Full)	0.65	0.45-0.92	0.015a	0.49	0.331-0.711	< 0.001a
EMT (Epithelial vs Mixed vs Mesenchymal)	1.36	1.06-1.74	0.016a	1.22	0.867-1.719	0.253
SOX2 expression (Positive vs Negative)	1.44	1.03- 2.03	0.034a	1.53	1.06-2.20	0.022a
Vimentin expression (Positive vs Negative)	1.51	1.06- 2.13	0.022a	1.37	0.83-2.26	0.224

^aP < 0.05, statistically significant. EMT: Epithelial-mesenchymal transition; SOX2: Sex determining region Y-box 2.