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©The Author(s) 2022.
World J Clin Cases. Sep 26, 2022; 10(27): 9657-9669
Published online Sep 26, 2022. doi: 10.12998/wjcc.v10.i27.9657
Published online Sep 26, 2022. doi: 10.12998/wjcc.v10.i27.9657
Table 2 Relationship of sex determining region Y-box 2, E-cadherin, and vimentin with demographic and clinical characteristics
| Characteristic | SOX2, n (%) | P value | E-cadherin, n (%) | P value | Vimentin, n (%) | P value | |||
| (-) | (+) | (-) | (+) | (-) | (+) | ||||
| Cases | 83 (44.9) | 102 (55.1) | 114 (61.6) | 71 (38.4) | 69 (37.3) | 116 (62.7) | |||
| Age, yr | |||||||||
| < 65 | 44 (53.0) | 56 (54.9) | 0.882 | 62 (54.4) | 38 (53.5) | 0.909 | 34 (49.3) | 66 (56.9) | 0.314 |
| ≥ 65 | 39 (47.0) | 46 (45.1) | 52 (45.6) | 33 (46.5) | 35 (50.7) | 50 (43.1) | |||
| Gender | |||||||||
| Male | 57 (68.7) | 72 (70.6) | 0.872 | 82 (71.9) | 47(66.2) | 0.409 | 53 (76.8) | 76 (65.5) | 0.106 |
| Female | 26 (31.3) | 30 (29.4) | 32 (28.1) | 24 (33.8) | 16 (23.2) | 40 (34.5) | |||
| Ethnicity | |||||||||
| Han | 49 (59.0) | 47 (46.1) | 0.103 | 62 (54.4) | 34 (47.9) | 0.390 | 38 (55.1) | 58 (50.0) | 0.504 |
| Kazakh | 34 (41.0) | 55 (53.9) | 52 (45.6) | 37 (52.1) | 31 (44.9) | 58 (50.0) | |||
| Tumor size | |||||||||
| < 3 cm | 71 (85.5) | 50 (49.0) | < 0.001a | 75 (65.8) | 46 (64.8) | 0.889 | 51 (73.9) | 70 (60.3) | 0.061 |
| ≥ 3 cm | 12 (14.5) | 52 (51.0) | 39 (34.2) | 25 (35.2) | 18 (26.1) | 46 (39.7) | |||
| Lymph node metastasis | |||||||||
| No | 60 (72.3) | 68 (66.7) | 0.428 | 76 (66.7) | 52 (73.2) | 0.346 | 53 (76.8) | 75 (64.7) | 0.083 |
| Yes | 23 (27.7) | 34 (33.3) | 38 (33.3) | 19 (26.8) | 16 (23.2) | 41 (35.3) | |||
| Tumor location | |||||||||
| Upper | 1 (1.2) | 7 (6.9) | 0.108 | 5 (4.4) | 3 (4.2) | 0.780 | 3 (4.3) | 5 (4.3) | 0.935 |
| Middle | 47 (56.6) | 50 (49.0) | 62 (54.4) | 35 (49.3) | 35 (50.7) | 62 (53.4) | |||
| Lower | 35 (42.2) | 45 (44.1) | 47 (41.2) | 33 (46.5) | 31 (44.9) | 49 (42.2) | |||
| Degree of differentiation | |||||||||
| High | 12 (14.5) | 11 (10.8) | 0.475 | 10(8.8) | 13 (18.3) | 0.035a | 9 (13.0) | 14 (12.1) | 0.953 |
| Moderate | 54 (65.1) | 63 (61.8) | 80 (70.2) | 37 (52.1) | 44 (63.8) | 73 (62.9) | |||
| Poor | 17 (20.5) | 28 (27.5) | 24 (21.1) | 21 (29.6) | 16 (23.2) | 29 (25.0) | |||
| AJCC stage | |||||||||
| I | 6 (7.2) | 9 (8.8) | 0.697 | 10(8.8) | 5(7.0) | 0.385 | 6 (8.7) | 9 (7.8) | 0.592 |
| II | 57 (68.7) | 62 (60.8) | 73 (64.0) | 46 (64.8) | 48 (69.6) | 71 (61.2) | |||
| III | 13 (15.7) | 22 (21.6) | 24(21.1) | 11 (15.5) | 10 (14.5) | 25 (21.6) | |||
| IV | 7 (8.4) | 9 (8.8) | 7 (6.1) | 9 (12.7) | 5 (7.2) | 11 (9.5) | |||
| T stage | |||||||||
| T1 | 3 (3.6) | 4 (3.9) | 0.333 | 5 (4.4) | 2 (2.8) | 0.887 | 2 (2.9) | 5 (4.3) | 0.059 |
| T2 | 41 (49.4) | 37 (36.3) | 49 (43.0) | 29 (40.8) | 37 (53.6) | 41 (35.3) | |||
| T3 | 36 (43.4) | 55 (53.9) | 54 (47.4 | 37 (52.1) | 29 (42.0) | 62 (53.4) | |||
| T4 | 3 (3.6) | 6 (5.9) | 6 (5.3) | 3 (4.2) | 1 (1.4) | 8 (6.9) | |||
| N stage | |||||||||
| N0 | 60 (72.3) | 68 (66.7) | 0.122 | 76 (66.7) | 52 (73.2) | 0.274 | 53 (76.8) | 75 (64.7) | 0.342 |
| N1 | 10 (12.0) | 23 (22.5) | 25 (21.9) | 8 (11.3) | 9 (13.0) | 24 (20.7) | |||
| N2 | 9 (10.8) | 10 (9.8) | 10(8.8) | 9(12.7) | 5 (7.2) | 14 (12.1) | |||
| N3 | 4 (4.8) | 1 (1.0) | 3 (2.6) | 2 (2.8) | 2 (2.9) | 3 (2.6) | |||
| M stage | |||||||||
| No | 81 (97.6) | 95 (93.1) | 0.190 | 111 (97.4) | 65(91.5) | 0.088 | 67 (97.1) | 109 (94.0) | 0.488 |
| Yes | 2 (2.4) | 7 (6.9) | 3 (2.6) | 6 (8.5) | 2 (2.9) | 7 (6.0) | |||
| Depth of invasion | |||||||||
| Mucosa | 35 (42.2) | 16(15.7) | < 0.001a | 29 (25.4) | 22 (31.0) | 0.412 | 27(39.1) | 24 (20.7) | 0.007a |
| Muscularis/Full thickness | 48(57.8) | 86 (84.3) | 85 (74.6) | 49 (69.0) | 42 (60.9) | 92 (79.3) | |||
- Citation: Li C, Ma YQ. Prognostic significance of sex determining region Y-box 2, E-cadherin, and vimentin in esophageal squamous cell carcinoma. World J Clin Cases 2022; 10(27): 9657-9669
- URL: https://www.wjgnet.com/2307-8960/full/v10/i27/9657.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v10.i27.9657